5-phenyl-1H-pyrazol-4-propionic acid derivatives, compositions and use

Compounds of formula I (I) wherein R1 is alkyl, alkoxy, alkylthio, alkylamino, aryl, aryloxy, arylthio, arylamino, aralkyl, aralkoxy, aralkylthio or aralkylamino, R2 and R3 are each independently hydrogen, halogen, hydroxy, mercapto, nitro or amino or have the meanings given for R1, and X is -NH2, -...

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HANS-JUERG
description Compounds of formula I (I) wherein R1 is alkyl, alkoxy, alkylthio, alkylamino, aryl, aryloxy, arylthio, arylamino, aralkyl, aralkoxy, aralkylthio or aralkylamino, R2 and R3 are each independently hydrogen, halogen, hydroxy, mercapto, nitro or amino or have the meanings given for R1, and X is -NH2, -NH-OH, -N(R4)OH, -NH-NH2 or -NH-N=C(R4)R5, wherein R4 and R5 are each alkyl, in free form or pharmaceutically acceptable salt form, have pharmaceutical utility, in particular in the treatment or prophylaxis of asthma, or in the treatment of inflammation or psoriasis.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title 5-phenyl-1H-pyrazol-4-propionic acid derivatives, compositions and use
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