Therapeutic virginiamycin M1 analogs
Virginiamycin M1 having the Formula: and virginiamycin M1 analogs having the Formulae I-IV: (I) (II) (III) (IV) Virginiamycin M1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of diso...
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| creator | LAM YIU-KUEN T CHANG RAYMOND S HENSENS OTTO D ZINK DEBORAH L SCHWARTZ CHERYL D |
| description | Virginiamycin M1 having the Formula: and virginiamycin M1 analogs having the Formulae I-IV: (I) (II) (III) (IV) Virginiamycin M1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527. The analog of Formula II is produced by chemical synthesis. |
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Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527. The analog of Formula II is produced by chemical synthesis.</description><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>1992</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19920811&DB=EPODOC&CC=US&NR=5137900A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19920811&DB=EPODOC&CC=US&NR=5137900A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LAM; YIU-KUEN T</creatorcontrib><creatorcontrib>CHANG; RAYMOND S</creatorcontrib><creatorcontrib>HENSENS; OTTO D</creatorcontrib><creatorcontrib>ZINK; DEBORAH L</creatorcontrib><creatorcontrib>SCHWARTZ; CHERYL D</creatorcontrib><title>Therapeutic virginiamycin M1 analogs</title><description>Virginiamycin M1 having the Formula: and virginiamycin M1 analogs having the Formulae I-IV: (I) (II) (III) (IV) Virginiamycin M1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527. The analog of Formula II is produced by chemical synthesis.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1992</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAJyUgtSixILS3JTFYoyyxKz8zLTMytTM7MU_A1VEjMS8zJTy_mYWBNS8wpTuWF0twM8m6uIc4euqkF-fGpxQWJyal5qSXxocGmhsbmlgYGjsaEVQAAhdcmIQ</recordid><startdate>19920811</startdate><enddate>19920811</enddate><creator>LAM; YIU-KUEN T</creator><creator>CHANG; RAYMOND S</creator><creator>HENSENS; OTTO D</creator><creator>ZINK; DEBORAH L</creator><creator>SCHWARTZ; CHERYL D</creator><scope>EVB</scope></search><sort><creationdate>19920811</creationdate><title>Therapeutic virginiamycin M1 analogs</title><author>LAM; YIU-KUEN T ; CHANG; RAYMOND S ; HENSENS; OTTO D ; ZINK; DEBORAH L ; SCHWARTZ; CHERYL D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US5137900A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1992</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>LAM; YIU-KUEN T</creatorcontrib><creatorcontrib>CHANG; RAYMOND S</creatorcontrib><creatorcontrib>HENSENS; OTTO D</creatorcontrib><creatorcontrib>ZINK; DEBORAH L</creatorcontrib><creatorcontrib>SCHWARTZ; CHERYL D</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LAM; YIU-KUEN T</au><au>CHANG; RAYMOND S</au><au>HENSENS; OTTO D</au><au>ZINK; DEBORAH L</au><au>SCHWARTZ; CHERYL D</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Therapeutic virginiamycin M1 analogs</title><date>1992-08-11</date><risdate>1992</risdate><abstract>Virginiamycin M1 having the Formula: and virginiamycin M1 analogs having the Formulae I-IV: (I) (II) (III) (IV) Virginiamycin M1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527. The analog of Formula II is produced by chemical synthesis.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Therapeutic virginiamycin M1 analogs |
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