Scattered total internal reflectance immunoassay system

Scattered total internal reflectance immunoassay system

A new immunoassay system is provided for the detection of ligands or ligand binding partners in solution in a heterogeneous format. The invention relies upon the detection of back scattered light from an evanescent wave disturbed by the presence of a colloidal gold label brought to the interface by...

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Hauptverfasser: HANSEN, WILLIAM P, GREENWOOD, DAVID L, DONDERO, RICHARD S, UTBERG, KARIN L, HOVORKA, GEORGE B, MEYER, RAYMOND E, SCHUTT, ERNEST G
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Sprache:eng
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INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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creator HANSEN
WILLIAM P
GREENWOOD
DAVID L
DONDERO
RICHARD S
UTBERG
KARIN L
HOVORKA
GEORGE B
MEYER
RAYMOND E
SCHUTT
ERNEST G
description A new immunoassay system is provided for the detection of ligands or ligand binding partners in solution in a heterogeneous format. The invention relies upon the detection of back scattered light from an evanescent wave disturbed by the presence of a colloidal gold label brought to the interface by an immunological reaction. The evanescent wave existing at the interface in turn is the result of a totally internally reflected incident light wave. Placement of the detector at a back angle above the critical angle insures a superior signal-to-noise ratio.
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subjects INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
title Scattered total internal reflectance immunoassay system
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