Barbituric acid derivative and treatment of leukemia and tumors therewith

Barbituric acid derivative and treatment of leukemia and tumors therewith

N-(2-Fluorophenyl)-1,2,3,4-tetrahydro-6-hydroxy-2,4-dioxo-5-pyrimidine carboxamide, useful for regressing or inhibiting the growth of leukemia and tumors in mammals. The compound has the formula: wherein R1 and R2 are selected from hydrogen or a cyclic or acyclic group which forms pyrimidine nucleos...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BREWER, ARTHUR D
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:N-(2-Fluorophenyl)-1,2,3,4-tetrahydro-6-hydroxy-2,4-dioxo-5-pyrimidine carboxamide, useful for regressing or inhibiting the growth of leukemia and tumors in mammals. The compound has the formula: wherein R1 and R2 are selected from hydrogen or a cyclic or acyclic group which forms pyrimidine nucleosides or pseudo nucleosides, and the pharmacologically acceptable acid addition salts thereof.