Proline-containing renin inhibitors

Proline-containing renin inhibitors

This invention concerns novel renin-inhibitory peptides containing proline which are useful for treating renin associated hypertension and for treating hyperaldosteronism. Intermediates and processes for preparing both the intermediates and the novel peptides, pharmaceutical compositions, and method...

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Hauptverfasser: LUNNEY, ELIZABETH A, NICOLAIDES, ERNEST D, KALTENBRONN, JAMES S
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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creator LUNNEY
ELIZABETH A
NICOLAIDES
ERNEST D
KALTENBRONN
JAMES S
description This invention concerns novel renin-inhibitory peptides containing proline which are useful for treating renin associated hypertension and for treating hyperaldosteronism. Intermediates and processes for preparing both the intermediates and the novel peptides, pharmaceutical compositions, and methods of treatment are included. Also included is a method of diagnosis of renin-associated hypertension using the compounds of the invention.
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subjects CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
title Proline-containing renin inhibitors
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