Novel sodium amoxicillin preparations

Novel sodium amoxicillin preparations

Novel sodium amoxicillin preparations which are easily converted into stable, suitably injectable solutions which are free of allergic reactions-causing chemicals and which contain besides sodium amoxicillin, a small amount of sodium hydroxide and optionally also a small amount of sodium chloride, a...

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Hauptverfasser: GROENENDAAL, JAN W, DE JONGE, HAYO, SIJBRANDS, GERRIT J, BAGERMAN-DEETMAN, ANNITA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator GROENENDAAL
JAN W
DE JONGE
HAYO
SIJBRANDS
GERRIT J
BAGERMAN-DEETMAN
ANNITA
description Novel sodium amoxicillin preparations which are easily converted into stable, suitably injectable solutions which are free of allergic reactions-causing chemicals and which contain besides sodium amoxicillin, a small amount of sodium hydroxide and optionally also a small amount of sodium chloride, and a process for their preparation and a process for the preparation of aqueous sodium amoxicillin containing injection solutions. The sodium amoxicillin preparations are prepared by the as fast but gradual addition as possible of an excess of sodium hydroxide to a suspension of amoxicillin trihydrate in water until the amoxicillin has completely dissolved, whereafter optionally a part of the excess of base is immediately neutralized with hydrochloric acid while the temperature is kept between 0 DEG -30 DEG C., followed by sterile filtration of the obtained solution, freezing the solution and freeze drying the obtained solid in flasks or in bulk.
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The sodium amoxicillin preparations are prepared by the as fast but gradual addition as possible of an excess of sodium hydroxide to a suspension of amoxicillin trihydrate in water until the amoxicillin has completely dissolved, whereafter optionally a part of the excess of base is immediately neutralized with hydrochloric acid while the temperature is kept between 0 DEG -30 DEG C., followed by sterile filtration of the obtained solution, freezing the solution and freeze drying the obtained solid in flasks or in bulk.</description><edition>4</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>1986</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=19860819&amp;DB=EPODOC&amp;CC=US&amp;NR=4607029A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=19860819&amp;DB=EPODOC&amp;CC=US&amp;NR=4607029A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GROENENDAAL; JAN W</creatorcontrib><creatorcontrib>DE JONGE; HAYO</creatorcontrib><creatorcontrib>SIJBRANDS; GERRIT J</creatorcontrib><creatorcontrib>BAGERMAN-DEETMAN; ANNITA</creatorcontrib><title>Novel sodium amoxicillin preparations</title><description>Novel sodium amoxicillin preparations which are easily converted into stable, suitably injectable solutions which are free of allergic reactions-causing chemicals and which contain besides sodium amoxicillin, a small amount of sodium hydroxide and optionally also a small amount of sodium chloride, and a process for their preparation and a process for the preparation of aqueous sodium amoxicillin containing injection solutions. 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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Novel sodium amoxicillin preparations
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