Ent-16-amino-17-hydroxy-oestra-1,3,5(10)-trienes and derivatives thereof, and pharmaceutical compositions
New and pharmacologically useful ent-16-amino-17-hydroxy-oestra-1,3,5(10)-trienes are disclosed having the formula I: I and pharmaceutically acceptable non-toxic acid addition salts thereof, wherein: n=1 or 2, preferably 1 R1=H or hydrocarbyl of 1 to 6 carbon atoms (preferably lower alkyl, such as m...
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| creator | ZEELEN FILIPPUS J |
| description | New and pharmacologically useful ent-16-amino-17-hydroxy-oestra-1,3,5(10)-trienes are disclosed having the formula I: I and pharmaceutically acceptable non-toxic acid addition salts thereof, wherein: n=1 or 2, preferably 1 R1=H or hydrocarbyl of 1 to 6 carbon atoms (preferably lower alkyl, such as methyl); R2=H or hydrocarbyl of 1 to 6 carbon atoms (preferably lower alkyl, such as methyl); or R1 and R2 together is alkylene of 4 or 5 carbon atoms; R3=a free, esterified or etherified hydroxyl group; and R4=a free, esterified or etherified hydroxyl group. The novel compounds have antiarrhythmic properties. |
| format | Patent |
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The novel compounds have antiarrhythmic properties.</description><language>eng</language><subject>CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; STEROIDS</subject><creationdate>1982</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19820518&DB=EPODOC&CC=US&NR=4330540A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19820518&DB=EPODOC&CC=US&NR=4330540A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZEELEN; FILIPPUS J</creatorcontrib><title>Ent-16-amino-17-hydroxy-oestra-1,3,5(10)-trienes and derivatives thereof, and pharmaceutical compositions</title><description>New and pharmacologically useful ent-16-amino-17-hydroxy-oestra-1,3,5(10)-trienes are disclosed having the formula I: I and pharmaceutically acceptable non-toxic acid addition salts thereof, wherein: n=1 or 2, preferably 1 R1=H or hydrocarbyl of 1 to 6 carbon atoms (preferably lower alkyl, such as methyl); R2=H or hydrocarbyl of 1 to 6 carbon atoms (preferably lower alkyl, such as methyl); or R1 and R2 together is alkylene of 4 or 5 carbon atoms; R3=a free, esterified or etherified hydroxyl group; and R4=a free, esterified or etherified hydroxyl group. The novel compounds have antiarrhythmic properties.</description><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>STEROIDS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1982</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFi0ELgkAQRr10iOo35LHAAZfVOkcY3atzDDrigO4su5Pkv0-ie6ePx3vfMuHKKZgD4MBOwByhm5og7wmEogYEk9ms3Jl8DxqYHMUUXZM2FHhE5XFm7SiQtNlX-A7DgDW9lGvs01oGL5GVxcV1smixj7T57SrZXqr7-Qrk5UnRzy9H-nzcCmvzsshP9n_xAdhuPfY</recordid><startdate>19820518</startdate><enddate>19820518</enddate><creator>ZEELEN; FILIPPUS J</creator><scope>EVB</scope></search><sort><creationdate>19820518</creationdate><title>Ent-16-amino-17-hydroxy-oestra-1,3,5(10)-trienes and derivatives thereof, and pharmaceutical compositions</title><author>ZEELEN; FILIPPUS J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US4330540A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1982</creationdate><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>STEROIDS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZEELEN; FILIPPUS J</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZEELEN; FILIPPUS J</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Ent-16-amino-17-hydroxy-oestra-1,3,5(10)-trienes and derivatives thereof, and pharmaceutical compositions</title><date>1982-05-18</date><risdate>1982</risdate><abstract>New and pharmacologically useful ent-16-amino-17-hydroxy-oestra-1,3,5(10)-trienes are disclosed having the formula I: I and pharmaceutically acceptable non-toxic acid addition salts thereof, wherein: n=1 or 2, preferably 1 R1=H or hydrocarbyl of 1 to 6 carbon atoms (preferably lower alkyl, such as methyl); R2=H or hydrocarbyl of 1 to 6 carbon atoms (preferably lower alkyl, such as methyl); or R1 and R2 together is alkylene of 4 or 5 carbon atoms; R3=a free, esterified or etherified hydroxyl group; and R4=a free, esterified or etherified hydroxyl group. The novel compounds have antiarrhythmic properties.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Ent-16-amino-17-hydroxy-oestra-1,3,5(10)-trienes and derivatives thereof, and pharmaceutical compositions |
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