Monophosphonate compounds as hypoglycemic and/or antiartherogenic agents
This invention relates to new monophosphonate compounds of formula X-C6H4-(O)m-(CH2)n-R where R is -PO3Me2, -PO3Et2, -PO3H2 or -PO3Na2, X is a halogen, preferably chlorine, in position o, m or p, preferably in position p; m is 0 or 1; and n is 0, 1, 2, 3, 4, 5 or 6, which possess remarkable activity...
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| creator | NGUYEN MONG LAN |
| description | This invention relates to new monophosphonate compounds of formula X-C6H4-(O)m-(CH2)n-R where R is -PO3Me2, -PO3Et2, -PO3H2 or -PO3Na2, X is a halogen, preferably chlorine, in position o, m or p, preferably in position p; m is 0 or 1; and n is 0, 1, 2, 3, 4, 5 or 6, which possess remarkable activity as hypoglycemic and/or antiatherogenic agents, and are usable in pharmaceutical compositions to alter lipoprotein profiles in favor of high density lipoproteins and to clear cholesterol from various tissues. |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Monophosphonate compounds as hypoglycemic and/or antiartherogenic agents |
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