Penicillin esters and their preparation

A class of esters of the penicillin, nafcillin have the general formula: wherein A is a C1-C6 alkylene group substituted with one or two groups of formula -NR1 R2 and optionally further substituted with one or more methyl or ethyl groups, wherein R1 and R2 are the same or different and each is a C1-...

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description A class of esters of the penicillin, nafcillin have the general formula: wherein A is a C1-C6 alkylene group substituted with one or two groups of formula -NR1 R2 and optionally further substituted with one or more methyl or ethyl groups, wherein R1 and R2 are the same or different and each is a C1-C6 alkyl group or R1 and R2 together with the nitrogen atom to which they are attached form a saturated 5- or 6- membered heterocyclic ring. Upon oral administration, the esters are absorbed into the bloodstream where they are hydrolyzed to release the antibacterially active parent penicillin, nafcillin.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Penicillin esters and their preparation
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