Process for the fermentation production of ergoline derivatives
Ergoline derivatives including alkaloids and 9,10-dihydroalkaloids of the ergotoxine group and including ergometrine are made by forming a submerged culture under aerobic conditions by inoculation of an aqueous medium containing a carbon source, an organic or inorganic nitrogen source or both of the...
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| creator | ERGE DIETER GRAWERT WERNER DAUTH CHRISTOPH KNOTHE EDDA BOROWSKI EVA HOHNE LISELOTTE NORDMANN GISELA SCHIRUTSCHKE RUDOLF BRAUN KLAUS VOLZKE KLAUS-DIETER GROGER DETLEV MULLER MONIKA BREUEL KLAUS |
| description | Ergoline derivatives including alkaloids and 9,10-dihydroalkaloids of the ergotoxine group and including ergometrine are made by forming a submerged culture under aerobic conditions by inoculation of an aqueous medium containing a carbon source, an organic or inorganic nitrogen source or both of these sources, and nutrient salts, the inoculum being spores obtained from a strain of Claviceps purpurea (Fr.) Tul. deposited under number IMET PA 130, and then, after completion of the cultivation, extracting the formed alkaloids from the culture and, if necessary, 9,10-dihydrogenating the extracted alkaloids, and converting the alkaloids into pharmaceutically acceptable acid addition salts. |
| format | Patent |
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DETLEV</au><au>MULLER; MONIKA</au><au>BREUEL; KLAUS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Process for the fermentation production of ergoline derivatives</title><date>1978-04-25</date><risdate>1978</risdate><abstract>Ergoline derivatives including alkaloids and 9,10-dihydroalkaloids of the ergotoxine group and including ergometrine are made by forming a submerged culture under aerobic conditions by inoculation of an aqueous medium containing a carbon source, an organic or inorganic nitrogen source or both of these sources, and nutrient salts, the inoculum being spores obtained from a strain of Claviceps purpurea (Fr.) Tul. deposited under number IMET PA 130, and then, after completion of the cultivation, extracting the formed alkaloids from the culture and, if necessary, 9,10-dihydrogenating the extracted alkaloids, and converting the alkaloids into pharmaceutically acceptable acid addition salts.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY SPIRITS TECHNICAL SUBJECTS COVERED BY FORMER USPC TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ARTCOLLECTIONS [XRACs] AND DIGESTS VINEGAR WINE |
| title | Process for the fermentation production of ergoline derivatives |
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