Process of preparing 1,3-bis(2-chloroethyl)-1-nitrosourea

A method of producing 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) by nitrosation of 1,3-bis(2-chloroethyl)-urea utilizing as a nitrosating agent dinitrogen trioxide (N2O3) in molar excess of theoretical wherein the molar excess of N2O3 ranges from 10-200% and preferably from 10-20%. The nitrosation...

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Bibliographische Detailangaben

Hauptverfasser:	SHARP, DONALD E, YANKO, WILLIAM H
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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