2,2{40 -Anhydro-1-{62 D-arabinofuranosyl-5-fluorocytosine salts and process 2

Reaction of 5-fluorocytidine with the Vilsmeier-Haack reagent followed by treatment of the reaction mixture with water or a lower alkanol directly yields the previously unknown hydrohalide salts of 2,2'-anhydro-1- beta -D-arabinofuranosyl-5-fluorocytosine as crystalline solids. These compounds...

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Hauptverfasser:	HOFFER, MAX
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS
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creator	HOFFER MAX
description	Reaction of 5-fluorocytidine with the Vilsmeier-Haack reagent followed by treatment of the reaction mixture with water or a lower alkanol directly yields the previously unknown hydrohalide salts of 2,2'-anhydro-1- beta -D-arabinofuranosyl-5-fluorocytosine as crystalline solids. These compounds are useful as orally or parenterally active immunorepressive or anti-neoplastic agents and as intermediates in the preparation of other acid addition salts, such as the formate of the base compound.
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subjects	CHEMISTRY DERIVATIVES THEREOF METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS
title	2,2{40 -Anhydro-1-{62 D-arabinofuranosyl-5-fluorocytosine salts and process 2
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