POTENTIATION OF ({31 ) CIS-1,2-EPOXYPROPYL)PHOSPHONIC ACID AND ANALOGUES THEREOF

POTENTIATION OF ({31 ) CIS-1,2-EPOXYPROPYL)PHOSPHONIC ACID AND ANALOGUES THEREOF

The activity of antibiotics is potentiated by compounds that stimulate the biosynthesis of transport mechanisms which mediate the entry of the antibiotic into the cell. Methods for finding such compounds and for using them to potentiate antibiotic activity are provided. Thus, phosphonomycin, its ana...

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Hauptverfasser: KAHAN F,US, CASSIDY P,US
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator KAHAN F,US
CASSIDY P,US
description The activity of antibiotics is potentiated by compounds that stimulate the biosynthesis of transport mechanisms which mediate the entry of the antibiotic into the cell. Methods for finding such compounds and for using them to potentiate antibiotic activity are provided. Thus, phosphonomycin, its analogs and derivatives thereof are potentiated by compounds capable of inducing directly or following metabolism the alpha -glycerophosphate or the hexose-6-phosphate transport systems of bacteria.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title POTENTIATION OF ({31 ) CIS-1,2-EPOXYPROPYL)PHOSPHONIC ACID AND ANALOGUES THEREOF
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