POTENTIATION OF ({31 ) CIS-1,2-EPOXYPROPYL)PHOSPHONIC ACID AND ANALOGUES THEREOF

POTENTIATION OF ({31 ) CIS-1,2-EPOXYPROPYL)PHOSPHONIC ACID AND ANALOGUES THEREOF

The activity of antibiotics is potentiated by compounds that stimulate the biosynthesis of transport mechanisms which mediate the entry of the antibiotic into the cell. Methods for finding such compounds and for using them to potentiate antibiotic activity are provided. Thus, phosphonomycin, its ana...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KAHAN F,US, CASSIDY P,US
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The activity of antibiotics is potentiated by compounds that stimulate the biosynthesis of transport mechanisms which mediate the entry of the antibiotic into the cell. Methods for finding such compounds and for using them to potentiate antibiotic activity are provided. Thus, phosphonomycin, its analogs and derivatives thereof are potentiated by compounds capable of inducing directly or following metabolism the alpha -glycerophosphate or the hexose-6-phosphate transport systems of bacteria.