DIBENZAZEPINE ACETIC ACID DERIVATIVES
(A) Cmpds. of general formula (I) Q = -CHR'CO2H and Q1 = H or Q = H and Q' = CHR'CO2H R1 = H or (1-3C) alkyl R2 = H or (1-4C) alkyl R3 = H or Cl (B) Salts of I. Anti-inflammatories, analgesic, and anti-pyretics. 5alpha-Dimethyl-10,11-dihydro-5H-dibenz(b,f) azepine-3-acetonitrile (3.4g...
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| creator | ALFRED SALLMANN KONRAD FITZI |
| description | (A) Cmpds. of general formula (I) Q = -CHR'CO2H and Q1 = H or Q = H and Q' = CHR'CO2H R1 = H or (1-3C) alkyl R2 = H or (1-4C) alkyl R3 = H or Cl (B) Salts of I. Anti-inflammatories, analgesic, and anti-pyretics. 5alpha-Dimethyl-10,11-dihydro-5H-dibenz(b,f) azepine-3-acetonitrile (3.4g) in CHCl3 (170 ml.) and EtOH (17 ml.), was satd. with HCl at 0-5 deg., and stirred 14h. at 20-25 deg. The soln. was concd., stirred 5h. at 40 deg. with dioxan (35 ml.) and H2O (7 ml.), evapd. and refluxed 1 h. with 5N-NaOH (10 ml.) and EtOH (35 ml.). The EtOH was distilled off, the soln. acidified (2N - HCl). extd. with EtOH, and the EtOAc extd. with 2N-Na2CO3. The Na2CO3 extracts were combined, acidified(2N-HCl), filtered, and recryst. from cyclohexane, giving the 3-acetic acid (I), m.p. 138-140 deg. |
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Anti-inflammatories, analgesic, and anti-pyretics. 5alpha-Dimethyl-10,11-dihydro-5H-dibenz(b,f) azepine-3-acetonitrile (3.4g) in CHCl3 (170 ml.) and EtOH (17 ml.), was satd. with HCl at 0-5 deg., and stirred 14h. at 20-25 deg. The soln. was concd., stirred 5h. at 40 deg. with dioxan (35 ml.) and H2O (7 ml.), evapd. and refluxed 1 h. with 5N-NaOH (10 ml.) and EtOH (35 ml.). The EtOH was distilled off, the soln. acidified (2N - HCl). extd. with EtOH, and the EtOAc extd. with 2N-Na2CO3. The Na2CO3 extracts were combined, acidified(2N-HCl), filtered, and recryst. from cyclohexane, giving the 3-acetic acid (I), m.p. 138-140 deg.</description><language>eng</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; CHEMISTRY ; FISHING ; FORESTRY ; HARVESTING ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HUNTING ; HYGIENE ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MOWING ; ORGANIC CHEMISTRY ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS ; TESTING ; TESTING STATIC OR DYNAMIC BALANCE OF MACHINES ORSTRUCTURES ; TESTING STRUCTURES OR APPARATUS NOT OTHERWISE PROVIDED FOR ; TRAPPING</subject><creationdate>1971</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19711130&DB=EPODOC&CC=US&NR=3624075A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19711130&DB=EPODOC&CC=US&NR=3624075A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ALFRED SALLMANN</creatorcontrib><creatorcontrib>KONRAD FITZI</creatorcontrib><title>DIBENZAZEPINE ACETIC ACID DERIVATIVES</title><description>(A) Cmpds. of general formula (I) Q = -CHR'CO2H and Q1 = H or Q = H and Q' = CHR'CO2H R1 = H or (1-3C) alkyl R2 = H or (1-4C) alkyl R3 = H or Cl (B) Salts of I. Anti-inflammatories, analgesic, and anti-pyretics. 5alpha-Dimethyl-10,11-dihydro-5H-dibenz(b,f) azepine-3-acetonitrile (3.4g) in CHCl3 (170 ml.) and EtOH (17 ml.), was satd. with HCl at 0-5 deg., and stirred 14h. at 20-25 deg. The soln. was concd., stirred 5h. at 40 deg. with dioxan (35 ml.) and H2O (7 ml.), evapd. and refluxed 1 h. with 5N-NaOH (10 ml.) and EtOH (35 ml.). The EtOH was distilled off, the soln. acidified (2N - HCl). extd. with EtOH, and the EtOAc extd. with 2N-Na2CO3. 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Anti-inflammatories, analgesic, and anti-pyretics. 5alpha-Dimethyl-10,11-dihydro-5H-dibenz(b,f) azepine-3-acetonitrile (3.4g) in CHCl3 (170 ml.) and EtOH (17 ml.), was satd. with HCl at 0-5 deg., and stirred 14h. at 20-25 deg. The soln. was concd., stirred 5h. at 40 deg. with dioxan (35 ml.) and H2O (7 ml.), evapd. and refluxed 1 h. with 5N-NaOH (10 ml.) and EtOH (35 ml.). The EtOH was distilled off, the soln. acidified (2N - HCl). extd. with EtOH, and the EtOAc extd. with 2N-Na2CO3. The Na2CO3 extracts were combined, acidified(2N-HCl), filtered, and recryst. from cyclohexane, giving the 3-acetic acid (I), m.p. 138-140 deg.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | AGRICULTURE ANIMAL HUSBANDRY CHEMISTRY FISHING FORESTRY HARVESTING HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING HYGIENE MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MOWING ORGANIC CHEMISTRY PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS TESTING TESTING STATIC OR DYNAMIC BALANCE OF MACHINES ORSTRUCTURES TESTING STRUCTURES OR APPARATUS NOT OTHERWISE PROVIDED FOR TRAPPING |
| title | DIBENZAZEPINE ACETIC ACID DERIVATIVES |
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