Process for stabilizing biologically active materials with modified collagen hydrolyzate
Biologically active, proteinaceous materials, e.g. bacteria, bacterial metabolites, viruses, sera and enzymes are protected from loss of activity by addition thereto of from 0.5 to 5% by weight of a cross-linked collagen degradation product which is either a) a collagen which is first hydrolytically...
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creator | SCHWICK HANS GERHARD SCHWEINSBERG HANS |
description | Biologically active, proteinaceous materials, e.g. bacteria, bacterial metabolites, viruses, sera and enzymes are protected from loss of activity by addition thereto of from 0.5 to 5% by weight of a cross-linked collagen degradation product which is either a) a collagen which is first hydrolytically degraded to a product having a M.W. of 2,000 to 20,000 which is then cross-linked with a polyfunctional isocyanate to yield a product with a M.W. of 15,000 to 60,000, or b) a collagen which is first cross-linked with a polyfunctional isocyanate and is then hydrobytically degraded to yield a product with a M.W. of 15,000 to 60,000. The examples relate to the stabilization of numerous vaccine materials, e.g. pertussis and BCG vaccines, diphtheria and tetanus toxoid, tuberculin, viruses, e.g. polio virus and Newcastle disease virus, sera e.g. rickettsia antiserum and enzymes e.g. plasmin and streptokinase. |
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The examples relate to the stabilization of numerous vaccine materials, e.g. pertussis and BCG vaccines, diphtheria and tetanus toxoid, tuberculin, viruses, e.g. polio virus and Newcastle disease virus, sera e.g. rickettsia antiserum and enzymes e.g. plasmin and streptokinase.</description><language>eng</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; BEER ; BIOCHEMISTRY ; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FISHING ; FORESTRY ; HUMAN NECESSITIES ; HUNTING ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PEST REPELLANTS OR ATTRACTANTS ; PLANT GROWTH REGULATORS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TRAPPING ; VINEGAR ; WINE</subject><creationdate>1967</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19670530&DB=EPODOC&CC=US&NR=3322632A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19670530&DB=EPODOC&CC=US&NR=3322632A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SCHWICK HANS GERHARD</creatorcontrib><creatorcontrib>SCHWEINSBERG HANS</creatorcontrib><title>Process for stabilizing biologically active materials with modified collagen hydrolyzate</title><description>Biologically active, proteinaceous materials, e.g. bacteria, bacterial metabolites, viruses, sera and enzymes are protected from loss of activity by addition thereto of from 0.5 to 5% by weight of a cross-linked collagen degradation product which is either a) a collagen which is first hydrolytically degraded to a product having a M.W. of 2,000 to 20,000 which is then cross-linked with a polyfunctional isocyanate to yield a product with a M.W. of 15,000 to 60,000, or b) a collagen which is first cross-linked with a polyfunctional isocyanate and is then hydrobytically degraded to yield a product with a M.W. of 15,000 to 60,000. The examples relate to the stabilization of numerous vaccine materials, e.g. pertussis and BCG vaccines, diphtheria and tetanus toxoid, tuberculin, viruses, e.g. polio virus and Newcastle disease virus, sera e.g. rickettsia antiserum and enzymes e.g. plasmin and streptokinase.</description><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FISHING</subject><subject>FORESTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PEST REPELLANTS OR ATTRACTANTS</subject><subject>PLANT GROWTH REGULATORS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>TRAPPING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1967</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFyrEKwjAQANAuDqJ-g_cDLgm4i1gcBRXcyjW5pAfXXkmC0n69Hdyd3vLW1euW1FHOEDRBLtiy8MxDhJZVNLJDkQnQFX4T9FgoMUqGD5cOevUcmDw4FcFIA3STTyrTvLxttQrLpN3PTbWvL4_z9UCjNpRHdDRQaZ53a405WnOy_8cXRPc6sg</recordid><startdate>19670530</startdate><enddate>19670530</enddate><creator>SCHWICK HANS GERHARD</creator><creator>SCHWEINSBERG HANS</creator><scope>EVB</scope></search><sort><creationdate>19670530</creationdate><title>Process for stabilizing biologically active materials with modified collagen hydrolyzate</title><author>SCHWICK HANS GERHARD ; SCHWEINSBERG HANS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US3322632A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1967</creationdate><topic>AGRICULTURE</topic><topic>ANIMAL HUSBANDRY</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FISHING</topic><topic>FORESTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HUNTING</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PEST REPELLANTS OR ATTRACTANTS</topic><topic>PLANT GROWTH REGULATORS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>TRAPPING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>SCHWICK HANS GERHARD</creatorcontrib><creatorcontrib>SCHWEINSBERG HANS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SCHWICK HANS GERHARD</au><au>SCHWEINSBERG HANS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Process for stabilizing biologically active materials with modified collagen hydrolyzate</title><date>1967-05-30</date><risdate>1967</risdate><abstract>Biologically active, proteinaceous materials, e.g. bacteria, bacterial metabolites, viruses, sera and enzymes are protected from loss of activity by addition thereto of from 0.5 to 5% by weight of a cross-linked collagen degradation product which is either a) a collagen which is first hydrolytically degraded to a product having a M.W. of 2,000 to 20,000 which is then cross-linked with a polyfunctional isocyanate to yield a product with a M.W. of 15,000 to 60,000, or b) a collagen which is first cross-linked with a polyfunctional isocyanate and is then hydrobytically degraded to yield a product with a M.W. of 15,000 to 60,000. The examples relate to the stabilization of numerous vaccine materials, e.g. pertussis and BCG vaccines, diphtheria and tetanus toxoid, tuberculin, viruses, e.g. polio virus and Newcastle disease virus, sera e.g. rickettsia antiserum and enzymes e.g. plasmin and streptokinase.</abstract><oa>free_for_read</oa></addata></record> |
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subjects | AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TRAPPING VINEGAR WINE |
title | Process for stabilizing biologically active materials with modified collagen hydrolyzate |
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