Hydrogenation process for the preparation of piperidyl-(4)-ethers

The invention comprises piperidyl-4-ethers of the general formula: in which R is an alkyl radical containing at least 2 carbon atoms. These compounds and the methyl ether are prepared by hydrogenating the corresponding pyridyl-4-ethers in the presence of a ruthenium catalyst, at an increased pressu...

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Hauptverfasser:	THIEL MAX, STACH KURT
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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creator	THIEL MAX STACH KURT
description	The invention comprises piperidyl-4-ethers of the general formula: in which R is an alkyl radical containing at least 2 carbon atoms. These compounds and the methyl ether are prepared by hydrogenating the corresponding pyridyl-4-ethers in the presence of a ruthenium catalyst, at an increased pressure and elevated temperature. Alternatively, the pyridyl-4-ether may be used as its N-oxide. The catalyst may be ruthenium metal, an oxide or a salt of ruthenium, or a ruthenate. The hydrogenation may be performed in the presence of small amounts of water and/or an alcohol, preferably corresponding to the alkoxy group in the ether. Compounds prepared include those in which R is methyl, ethyl, n-propyl and isopropyl.
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These compounds and the methyl ether are prepared by hydrogenating the corresponding pyridyl-4-ethers in the presence of a ruthenium catalyst, at an increased pressure and elevated temperature. Alternatively, the pyridyl-4-ether may be used as its N-oxide. The catalyst may be ruthenium metal, an oxide or a salt of ruthenium, or a ruthenate. The hydrogenation may be performed in the presence of small amounts of water and/or an alcohol, preferably corresponding to the alkoxy group in the ether. Compounds prepared include those in which R is methyl, ethyl, n-propyl and isopropyl.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1966</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19661122&DB=EPODOC&CC=US&NR=3287460A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19661122&DB=EPODOC&CC=US&NR=3287460A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>THIEL MAX</creatorcontrib><creatorcontrib>STACH KURT</creatorcontrib><title>Hydrogenation process for the preparation of piperidyl-(4)-ethers</title><description>The invention comprises piperidyl-4-ethers of the general formula: <FORM:0957149/C2/1> in which R is an alkyl radical containing at least 2 carbon atoms. These compounds and the methyl ether are prepared by hydrogenating the corresponding pyridyl-4-ethers in the presence of a ruthenium catalyst, at an increased pressure and elevated temperature. Alternatively, the pyridyl-4-ether may be used as its N-oxide. The catalyst may be ruthenium metal, an oxide or a salt of ruthenium, or a ruthenate. The hydrogenation may be performed in the presence of small amounts of water and/or an alcohol, preferably corresponding to the alkoxy group in the ether. Compounds prepared include those in which R is methyl, ethyl, n-propyl and isopropyl.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1966</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHD0qEwpyk9PzUssyczPUygoyk9OLS5WSMsvUijJSAXyUwsSiyBy-WkKBZkFqUWZKZU5uhommrqpQBVFxTwMrGmJOcWpvFCam0HezTXE2UM3tSA_PrW4IDE5NS-1JD402NjIwtzEzMDRmLAKAE1MMOY</recordid><startdate>19661122</startdate><enddate>19661122</enddate><creator>THIEL MAX</creator><creator>STACH KURT</creator><scope>EVB</scope></search><sort><creationdate>19661122</creationdate><title>Hydrogenation process for the preparation of piperidyl-(4)-ethers</title><author>THIEL MAX ; STACH KURT</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US3287460A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1966</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>THIEL MAX</creatorcontrib><creatorcontrib>STACH KURT</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>THIEL MAX</au><au>STACH KURT</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Hydrogenation process for the preparation of piperidyl-(4)-ethers</title><date>1966-11-22</date><risdate>1966</risdate><abstract>The invention comprises piperidyl-4-ethers of the general formula: <FORM:0957149/C2/1> in which R is an alkyl radical containing at least 2 carbon atoms. These compounds and the methyl ether are prepared by hydrogenating the corresponding pyridyl-4-ethers in the presence of a ruthenium catalyst, at an increased pressure and elevated temperature. Alternatively, the pyridyl-4-ether may be used as its N-oxide. The catalyst may be ruthenium metal, an oxide or a salt of ruthenium, or a ruthenate. The hydrogenation may be performed in the presence of small amounts of water and/or an alcohol, preferably corresponding to the alkoxy group in the ether. Compounds prepared include those in which R is methyl, ethyl, n-propyl and isopropyl.</abstract><oa>free_for_read</oa></addata></record>
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title	Hydrogenation process for the preparation of piperidyl-(4)-ethers
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