Recrystallization of demethylchlortetracycline

Recrystallization of demethylchlortetracycline

A process of recovering demethylchlortetracycline in the form of an inorganic acid salt thereof, from crude demethylchlortetracycline containing demethyltetracycline, comprises dissolving such crude demethylchlortetracycline in water by the addition of an alkali metal hydroxide to an aqueous slurry...

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Hauptverfasser: ORIGONI VICTOR EMIL, WINTERBOTTOM ROBERT
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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creator ORIGONI VICTOR EMIL
WINTERBOTTOM ROBERT
description A process of recovering demethylchlortetracycline in the form of an inorganic acid salt thereof, from crude demethylchlortetracycline containing demethyltetracycline, comprises dissolving such crude demethylchlortetracycline in water by the addition of an alkali metal hydroxide to an aqueous slurry of the crude demethylchlortetracycline, filtering the solution to remove insoluble impurities and acidifying the filtrate with an inorganic acid, whereby the inorganic acid salt of demethylchlortetracycline substantially free from demethyltetracycline is precipitated. The alkali metal hydroxide is preferably added to a pH of 7-9 and is desirably sodium or potassium hydroxide. The filtrate is acidified to a pH of 0.5-1 and preferably 0.6-0.7. A specified inorganic acid salt of demethylchlortetracycline is the hydrochloride.
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The alkali metal hydroxide is preferably added to a pH of 7-9 and is desirably sodium or potassium hydroxide. The filtrate is acidified to a pH of 0.5-1 and preferably 0.6-0.7. 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The alkali metal hydroxide is preferably added to a pH of 7-9 and is desirably sodium or potassium hydroxide. The filtrate is acidified to a pH of 0.5-1 and preferably 0.6-0.7. A specified inorganic acid salt of demethylchlortetracycline is the hydrochloride.</abstract><oa>free_for_read</oa></addata></record>
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
title Recrystallization of demethylchlortetracycline
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