METHODS AND COMPOSITIONS FOR IMPROVED SNP DISCRIMINATION
Compositions and methods for improved SNP discrimination are provided. An exemplary composition comprises a programmable nuclease and a non-naturally occurring guide nucleic acid that hybridizes to a target nucleic acid, or segment thereof, comprising at least one single-nucleotide polymorphism (SNP...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | BROUGHTON, James Paul HENDRIKS, Carley Gelenter CHEN, Janice Sha CHING, Jesus MCKAY, Bridget Ann Paine FASCHING, Clare Louise |
| description | Compositions and methods for improved SNP discrimination are provided. An exemplary composition comprises a programmable nuclease and a non-naturally occurring guide nucleic acid that hybridizes to a target nucleic acid, or segment thereof, comprising at least one single-nucleotide polymorphism (SNP). Methods may comprise a) contacting the sample to: i) a detector nucleic acid and ii) the composition; and b) assaying for a signal indicative of cleavage of the detector nucleic acid by the first programmable nuclease. In an exemplary embodiment, the target nucleic acid is a coronavirus target nucleic acid. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2024401158A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2024401158A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2024401158A13</originalsourceid><addsrcrecordid>eNrjZLDwdQ3x8HcJVnD0c1Fw9vcN8A_2DPH09wtWcPMPUvD0DQjyD3N1UQj2C1Bw8Qx2DvL09fRzBCngYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXxocFGBkYmJgaGhqYWjobGxKkCACk8KbI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>METHODS AND COMPOSITIONS FOR IMPROVED SNP DISCRIMINATION</title><source>esp@cenet</source><creator>BROUGHTON, James Paul ; HENDRIKS, Carley Gelenter ; CHEN, Janice Sha ; CHING, Jesus ; MCKAY, Bridget Ann Paine ; FASCHING, Clare Louise</creator><creatorcontrib>BROUGHTON, James Paul ; HENDRIKS, Carley Gelenter ; CHEN, Janice Sha ; CHING, Jesus ; MCKAY, Bridget Ann Paine ; FASCHING, Clare Louise</creatorcontrib><description>Compositions and methods for improved SNP discrimination are provided. An exemplary composition comprises a programmable nuclease and a non-naturally occurring guide nucleic acid that hybridizes to a target nucleic acid, or segment thereof, comprising at least one single-nucleotide polymorphism (SNP). Methods may comprise a) contacting the sample to: i) a detector nucleic acid and ii) the composition; and b) assaying for a signal indicative of cleavage of the detector nucleic acid by the first programmable nuclease. In an exemplary embodiment, the target nucleic acid is a coronavirus target nucleic acid.</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241205&DB=EPODOC&CC=US&NR=2024401158A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241205&DB=EPODOC&CC=US&NR=2024401158A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BROUGHTON, James Paul</creatorcontrib><creatorcontrib>HENDRIKS, Carley Gelenter</creatorcontrib><creatorcontrib>CHEN, Janice Sha</creatorcontrib><creatorcontrib>CHING, Jesus</creatorcontrib><creatorcontrib>MCKAY, Bridget Ann Paine</creatorcontrib><creatorcontrib>FASCHING, Clare Louise</creatorcontrib><title>METHODS AND COMPOSITIONS FOR IMPROVED SNP DISCRIMINATION</title><description>Compositions and methods for improved SNP discrimination are provided. An exemplary composition comprises a programmable nuclease and a non-naturally occurring guide nucleic acid that hybridizes to a target nucleic acid, or segment thereof, comprising at least one single-nucleotide polymorphism (SNP). Methods may comprise a) contacting the sample to: i) a detector nucleic acid and ii) the composition; and b) assaying for a signal indicative of cleavage of the detector nucleic acid by the first programmable nuclease. In an exemplary embodiment, the target nucleic acid is a coronavirus target nucleic acid.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLDwdQ3x8HcJVnD0c1Fw9vcN8A_2DPH09wtWcPMPUvD0DQjyD3N1UQj2C1Bw8Qx2DvL09fRzBCngYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXxocFGBkYmJgaGhqYWjobGxKkCACk8KbI</recordid><startdate>20241205</startdate><enddate>20241205</enddate><creator>BROUGHTON, James Paul</creator><creator>HENDRIKS, Carley Gelenter</creator><creator>CHEN, Janice Sha</creator><creator>CHING, Jesus</creator><creator>MCKAY, Bridget Ann Paine</creator><creator>FASCHING, Clare Louise</creator><scope>EVB</scope></search><sort><creationdate>20241205</creationdate><title>METHODS AND COMPOSITIONS FOR IMPROVED SNP DISCRIMINATION</title><author>BROUGHTON, James Paul ; HENDRIKS, Carley Gelenter ; CHEN, Janice Sha ; CHING, Jesus ; MCKAY, Bridget Ann Paine ; FASCHING, Clare Louise</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2024401158A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>BROUGHTON, James Paul</creatorcontrib><creatorcontrib>HENDRIKS, Carley Gelenter</creatorcontrib><creatorcontrib>CHEN, Janice Sha</creatorcontrib><creatorcontrib>CHING, Jesus</creatorcontrib><creatorcontrib>MCKAY, Bridget Ann Paine</creatorcontrib><creatorcontrib>FASCHING, Clare Louise</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BROUGHTON, James Paul</au><au>HENDRIKS, Carley Gelenter</au><au>CHEN, Janice Sha</au><au>CHING, Jesus</au><au>MCKAY, Bridget Ann Paine</au><au>FASCHING, Clare Louise</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHODS AND COMPOSITIONS FOR IMPROVED SNP DISCRIMINATION</title><date>2024-12-05</date><risdate>2024</risdate><abstract>Compositions and methods for improved SNP discrimination are provided. An exemplary composition comprises a programmable nuclease and a non-naturally occurring guide nucleic acid that hybridizes to a target nucleic acid, or segment thereof, comprising at least one single-nucleotide polymorphism (SNP). Methods may comprise a) contacting the sample to: i) a detector nucleic acid and ii) the composition; and b) assaying for a signal indicative of cleavage of the detector nucleic acid by the first programmable nuclease. In an exemplary embodiment, the target nucleic acid is a coronavirus target nucleic acid.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_US2024401158A1 |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE |
| title | METHODS AND COMPOSITIONS FOR IMPROVED SNP DISCRIMINATION |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T15%3A26%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=BROUGHTON,%20James%20Paul&rft.date=2024-12-05&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS2024401158A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |