FUSION PROTEIN OF VHH ANTIBODY AND STREPTAVIDIN MUTANT

FUSION PROTEIN OF VHH ANTIBODY AND STREPTAVIDIN MUTANT

A fusion protein of a molecule that recognizes cancer cells or the like and a mutant streptavidin, wherein the fusion protein is for use in the treatment or diagnosis of a cancer, is provided. In the fusion protein, a VHH antibody is bound, via a linker sequence, to the N-terminal side and/or C-term...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: KODAMA, Tatsuhiko, CHANSLER, Michael, NAKAI, Masanori, TATSUMI, Toshifumi, SUGIYAMA, Akira, TOKUYAMA, Hidetoshi, TANAKA, Toshiya, KANAI, Motomu, TSUKAGOSHI, Masanobu, SAKATA, Juri, YAMATSUGU, Kenzo
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A fusion protein of a molecule that recognizes cancer cells or the like and a mutant streptavidin, wherein the fusion protein is for use in the treatment or diagnosis of a cancer, is provided. In the fusion protein, a VHH antibody is bound, via a linker sequence, to the N-terminal side and/or C-terminal side of the amino acid sequence as set forth in SEQ ID NO: 1, provided that the C-terminal amino acid sequence consisting of Pro-Ser-Ala-Ala-Ser-His-His-His-His-His-His may be partially or entirely deleted.