GUANINE-RICH DEOXYRIBOZYMES, COMPOSITIONS AND USES THEREOF
Provided herein are modified DNAzymes, including DNAzymes with overhang sequences not complementary to the target RNA, in particular, overhangs with high G content. Also provided are compositions comprising the DNAzyme; vectors including the DNAzymes; pharmaceutical compositions including the vector...
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| creator | ROSENBERG, Alexander LEVY-ZAMIR, Adva KATZ-KADOSH, Etti KNANY, Alaa BOROVSKY, Noam COHEN, Noam BACHELET, Ido RAICHLIN, Dina MARMOR-KOLLET, Hagai OVADYA, Yossi BARAKEY, Shireen ABU-HOROWITZ, Almogit KRIEGER, Gat |
| description | Provided herein are modified DNAzymes, including DNAzymes with overhang sequences not complementary to the target RNA, in particular, overhangs with high G content. Also provided are compositions comprising the DNAzyme; vectors including the DNAzymes; pharmaceutical compositions including the vectors; and methods including any of the above for cleaving a target RNA; inducing cell death; and treating various diseases and disorders. |
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Also provided are compositions comprising the DNAzyme; vectors including the DNAzymes; pharmaceutical compositions including the vectors; and methods including any of the above for cleaving a target RNA; inducing cell death; and treating various diseases and disorders.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | GUANINE-RICH DEOXYRIBOZYMES, COMPOSITIONS AND USES THEREOF |
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