GUANINE-RICH DEOXYRIBOZYMES, COMPOSITIONS AND USES THEREOF

Provided herein are modified DNAzymes, including DNAzymes with overhang sequences not complementary to the target RNA, in particular, overhangs with high G content. Also provided are compositions comprising the DNAzyme; vectors including the DNAzymes; pharmaceutical compositions including the vector...

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Bibliographische Detailangaben
Hauptverfasser:	ROSENBERG, Alexander, LEVY-ZAMIR, Adva, KATZ-KADOSH, Etti, KNANY, Alaa, BOROVSKY, Noam, COHEN, Noam, BACHELET, Ido, RAICHLIN, Dina, MARMOR-KOLLET, Hagai, OVADYA, Yossi, BARAKEY, Shireen, ABU-HOROWITZ, Almogit, KRIEGER, Gat
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein are modified DNAzymes, including DNAzymes with overhang sequences not complementary to the target RNA, in particular, overhangs with high G content. Also provided are compositions comprising the DNAzyme; vectors including the DNAzymes; pharmaceutical compositions including the vectors; and methods including any of the above for cleaving a target RNA; inducing cell death; and treating various diseases and disorders.