PROCESS FOR PURIFICATION OF PROTEIN
The present invention relates to purification process of pharmacologically active IgG1 containing protein comprising at least affinity chromatography followed by mixed-mode chromatography. The present invention provides cytotoxic T-lymphocyte-associated 4-immunoglobulin (CTLA4-Ig) fusion protein by...
Gespeichert in:
Hauptverfasser: | , , , |
---|---|
Format: | Patent |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext bestellen |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | |
container_start_page | |
container_title | |
container_volume | |
creator | Upadhyay, Roshan Ganeshlal Gupta, Tarun Kumar Thakkar, Mayankkumar Narayan, Om |
description | The present invention relates to purification process of pharmacologically active IgG1 containing protein comprising at least affinity chromatography followed by mixed-mode chromatography. The present invention provides cytotoxic T-lymphocyte-associated 4-immunoglobulin (CTLA4-Ig) fusion protein by using at least affinity chromatography, mixed-mode chromatography and optionally one or more suitable purification steps that provides purified composition of the fusion protein, substantially free of impurities selected from Pre-Peak, product and process related impurities. Further, the present invention provides highly purified CTLA4-Ig fusion protein with reduced heterogeneity. |
format | Patent |
fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2024317799A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2024317799A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2024317799A13</originalsourceid><addsrcrecordid>eNrjZFAOCPJ3dg0OVnDzD1IICA3ydPN0dgzx9PdT8HdTAMqFuHr68TCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSS-NBgIwMjE2NDc3NLS0dDY-JUAQD14SPf</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PROCESS FOR PURIFICATION OF PROTEIN</title><source>esp@cenet</source><creator>Upadhyay, Roshan Ganeshlal ; Gupta, Tarun Kumar ; Thakkar, Mayankkumar ; Narayan, Om</creator><creatorcontrib>Upadhyay, Roshan Ganeshlal ; Gupta, Tarun Kumar ; Thakkar, Mayankkumar ; Narayan, Om</creatorcontrib><description>The present invention relates to purification process of pharmacologically active IgG1 containing protein comprising at least affinity chromatography followed by mixed-mode chromatography. The present invention provides cytotoxic T-lymphocyte-associated 4-immunoglobulin (CTLA4-Ig) fusion protein by using at least affinity chromatography, mixed-mode chromatography and optionally one or more suitable purification steps that provides purified composition of the fusion protein, substantially free of impurities selected from Pre-Peak, product and process related impurities. Further, the present invention provides highly purified CTLA4-Ig fusion protein with reduced heterogeneity.</description><language>eng</language><subject>CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240926&DB=EPODOC&CC=US&NR=2024317799A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240926&DB=EPODOC&CC=US&NR=2024317799A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Upadhyay, Roshan Ganeshlal</creatorcontrib><creatorcontrib>Gupta, Tarun Kumar</creatorcontrib><creatorcontrib>Thakkar, Mayankkumar</creatorcontrib><creatorcontrib>Narayan, Om</creatorcontrib><title>PROCESS FOR PURIFICATION OF PROTEIN</title><description>The present invention relates to purification process of pharmacologically active IgG1 containing protein comprising at least affinity chromatography followed by mixed-mode chromatography. The present invention provides cytotoxic T-lymphocyte-associated 4-immunoglobulin (CTLA4-Ig) fusion protein by using at least affinity chromatography, mixed-mode chromatography and optionally one or more suitable purification steps that provides purified composition of the fusion protein, substantially free of impurities selected from Pre-Peak, product and process related impurities. Further, the present invention provides highly purified CTLA4-Ig fusion protein with reduced heterogeneity.</description><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAOCPJ3dg0OVnDzD1IICA3ydPN0dgzx9PdT8HdTAMqFuHr68TCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSS-NBgIwMjE2NDc3NLS0dDY-JUAQD14SPf</recordid><startdate>20240926</startdate><enddate>20240926</enddate><creator>Upadhyay, Roshan Ganeshlal</creator><creator>Gupta, Tarun Kumar</creator><creator>Thakkar, Mayankkumar</creator><creator>Narayan, Om</creator><scope>EVB</scope></search><sort><creationdate>20240926</creationdate><title>PROCESS FOR PURIFICATION OF PROTEIN</title><author>Upadhyay, Roshan Ganeshlal ; Gupta, Tarun Kumar ; Thakkar, Mayankkumar ; Narayan, Om</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2024317799A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><toplevel>online_resources</toplevel><creatorcontrib>Upadhyay, Roshan Ganeshlal</creatorcontrib><creatorcontrib>Gupta, Tarun Kumar</creatorcontrib><creatorcontrib>Thakkar, Mayankkumar</creatorcontrib><creatorcontrib>Narayan, Om</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Upadhyay, Roshan Ganeshlal</au><au>Gupta, Tarun Kumar</au><au>Thakkar, Mayankkumar</au><au>Narayan, Om</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR PURIFICATION OF PROTEIN</title><date>2024-09-26</date><risdate>2024</risdate><abstract>The present invention relates to purification process of pharmacologically active IgG1 containing protein comprising at least affinity chromatography followed by mixed-mode chromatography. The present invention provides cytotoxic T-lymphocyte-associated 4-immunoglobulin (CTLA4-Ig) fusion protein by using at least affinity chromatography, mixed-mode chromatography and optionally one or more suitable purification steps that provides purified composition of the fusion protein, substantially free of impurities selected from Pre-Peak, product and process related impurities. Further, the present invention provides highly purified CTLA4-Ig fusion protein with reduced heterogeneity.</abstract><oa>free_for_read</oa></addata></record> |
fulltext | fulltext_linktorsrc |
identifier | |
ispartof | |
issn | |
language | eng |
recordid | cdi_epo_espacenet_US2024317799A1 |
source | esp@cenet |
subjects | CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES |
title | PROCESS FOR PURIFICATION OF PROTEIN |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T19%3A25%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Upadhyay,%20Roshan%20Ganeshlal&rft.date=2024-09-26&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS2024317799A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |