FimH Mutant, Compositions Therewith And Use Thereof

FimH Mutant, Compositions Therewith And Use Thereof

Polypeptides comprising a FimH lectin domain comprising an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject...

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Hauptverfasser: WEERDENBURG, Marleen Eveline, GRIJPSTRA, Jan, FEITSMA, Jakob Louris, FAE, Cristhina Kellen, GEURTSEN, Jeroen
Format: Patent
Sprache:eng
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CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator WEERDENBURG, Marleen Eveline
GRIJPSTRA, Jan
FEITSMA, Jakob Louris
FAE, Cristhina Kellen
GEURTSEN, Jeroen
description Polypeptides comprising a FimH lectin domain comprising an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject in need thereof by administration of the polypeptide are further described.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title FimH Mutant, Compositions Therewith And Use Thereof
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