METHOD AND APPARATUS FOR FORMING A MICROFLUIDIC GEL STRUCTURE
A method for creating a lumenized gel structure is described. The method comprises introducing a first liquid comprising a gel precursor solution into a microfluidic network, the microfluidic network comprising a capillary pressure barrier at a position generally defining a boundary between first an...
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| creator | Trietsch, Sebastiaan Johannes Burton, Todd Peter Al-Mardini, Claudia |
| description | A method for creating a lumenized gel structure is described. The method comprises introducing a first liquid comprising a gel precursor solution into a microfluidic network, the microfluidic network comprising a capillary pressure barrier at a position generally defining a boundary between first and second regions of the microfluidic network; allowing the first liquid to enter the first region of the microfluidic network and align itself along the capillary pressure barrier, thereby forming a liquid-air meniscus of the first liquid at the boundary between the first and second regions of the microfluidic network; forming a lumen through the first liquid by contacting the first liquid with a second liquid, wherein the second liquid has a viscosity which is lower than the viscosity of the first liquid; and allowing or causing the first liquid to gelate to form a gel structure comprising a lumen therethrough. Also described is an apparatus comprising a gel with a lumen extending therethrough, and uses of the apparatus and the lumenized gel structure in assays. |
| format | Patent |
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The method comprises introducing a first liquid comprising a gel precursor solution into a microfluidic network, the microfluidic network comprising a capillary pressure barrier at a position generally defining a boundary between first and second regions of the microfluidic network; allowing the first liquid to enter the first region of the microfluidic network and align itself along the capillary pressure barrier, thereby forming a liquid-air meniscus of the first liquid at the boundary between the first and second regions of the microfluidic network; forming a lumen through the first liquid by contacting the first liquid with a second liquid, wherein the second liquid has a viscosity which is lower than the viscosity of the first liquid; and allowing or causing the first liquid to gelate to form a gel structure comprising a lumen therethrough. Also described is an apparatus comprising a gel with a lumen extending therethrough, and uses of the apparatus and the lumenized gel structure in assays.</description><language>eng</language><subject>APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY ; BEER ; BIOCHEMISTRY ; CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE ; CHEMISTRY ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; SPIRITS ; TRANSPORTING ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240815&DB=EPODOC&CC=US&NR=2024271071A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240815&DB=EPODOC&CC=US&NR=2024271071A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Trietsch, Sebastiaan Johannes</creatorcontrib><creatorcontrib>Burton, Todd Peter</creatorcontrib><creatorcontrib>Al-Mardini, Claudia</creatorcontrib><title>METHOD AND APPARATUS FOR FORMING A MICROFLUIDIC GEL STRUCTURE</title><description>A method for creating a lumenized gel structure is described. The method comprises introducing a first liquid comprising a gel precursor solution into a microfluidic network, the microfluidic network comprising a capillary pressure barrier at a position generally defining a boundary between first and second regions of the microfluidic network; allowing the first liquid to enter the first region of the microfluidic network and align itself along the capillary pressure barrier, thereby forming a liquid-air meniscus of the first liquid at the boundary between the first and second regions of the microfluidic network; forming a lumen through the first liquid by contacting the first liquid with a second liquid, wherein the second liquid has a viscosity which is lower than the viscosity of the first liquid; and allowing or causing the first liquid to gelate to form a gel structure comprising a lumen therethrough. 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The method comprises introducing a first liquid comprising a gel precursor solution into a microfluidic network, the microfluidic network comprising a capillary pressure barrier at a position generally defining a boundary between first and second regions of the microfluidic network; allowing the first liquid to enter the first region of the microfluidic network and align itself along the capillary pressure barrier, thereby forming a liquid-air meniscus of the first liquid at the boundary between the first and second regions of the microfluidic network; forming a lumen through the first liquid by contacting the first liquid with a second liquid, wherein the second liquid has a viscosity which is lower than the viscosity of the first liquid; and allowing or causing the first liquid to gelate to form a gel structure comprising a lumen therethrough. Also described is an apparatus comprising a gel with a lumen extending therethrough, and uses of the apparatus and the lumenized gel structure in assays.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE CHEMISTRY ENZYMOLOGY METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL SPIRITS TRANSPORTING VINEGAR WINE |
| title | METHOD AND APPARATUS FOR FORMING A MICROFLUIDIC GEL STRUCTURE |
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