GLP1/GIP/NPY2 RECEPTOR TRIPLE AGONISTS

Hybrid polypeptides that agonize the GIP, GLP-1 and neuropeptide Y2 (NPY2) receptors and their medical use in the treatment of a variety of diseases, conditions or disorders, such as obesity, diabetes, and/or NASH are disclosed. The polypeptides have the general structure Z1-Z2-Z3, wherein Z1 is a h...

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Hauptverfasser:	AUGUSTIN, Robert, HAEBEL, Peter Wilhelm, MURRAY, Anthony, MADSEN, Charlotte Stahl, TEUFEL, Daniel Paul
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	AUGUSTIN, Robert HAEBEL, Peter Wilhelm MURRAY, Anthony MADSEN, Charlotte Stahl TEUFEL, Daniel Paul
description	Hybrid polypeptides that agonize the GIP, GLP-1 and neuropeptide Y2 (NPY2) receptors and their medical use in the treatment of a variety of diseases, conditions or disorders, such as obesity, diabetes, and/or NASH are disclosed. The polypeptides have the general structure Z1-Z2-Z3, wherein Z1 is a hybrid polypeptide providing GIPR and GLP1R agonism, Z2 is a linker, and Z3 is a polypeptide providing hY2R agonism.
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title	GLP1/GIP/NPY2 RECEPTOR TRIPLE AGONISTS
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