ARYL 3-OXOPIPERAZINE CARBOXAMIDES AND HETEROARYL 3-OXOPIPERAZINE CARBOXAMIDES AS NAV1.8 INHIBITORS
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | Liu, Jian Shah, Akshay A Cox, Jason M Layton, Mark Eric Bell, Ian M Kelly, III, Michael J Arasappan, Ashok Liu, Hong VanHeyst, Michael D |
| description | Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2024246932A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2024246932A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2024246932A13</originalsourceid><addsrcrecordid>eNrjZEhyDIr0UTDW9Y_wD_AMcA1yjPL0c1Vwdgxy8o9w9PV0cQ1WcPRzUfBwDXEN8idCbbCCn2OYoZ6Fgqefh6eTZ4h_UDAPA2taYk5xKi-U5mZQdnMNcfbQTS3Ij08tLkhMTs1LLYkPDTYyMDIxMjGzNDZyNDQmThUAwek09A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>ARYL 3-OXOPIPERAZINE CARBOXAMIDES AND HETEROARYL 3-OXOPIPERAZINE CARBOXAMIDES AS NAV1.8 INHIBITORS</title><source>esp@cenet</source><creator>Liu, Jian ; Shah, Akshay A ; Cox, Jason M ; Layton, Mark Eric ; Bell, Ian M ; Kelly, III, Michael J ; Arasappan, Ashok ; Liu, Hong ; VanHeyst, Michael D</creator><creatorcontrib>Liu, Jian ; Shah, Akshay A ; Cox, Jason M ; Layton, Mark Eric ; Bell, Ian M ; Kelly, III, Michael J ; Arasappan, Ashok ; Liu, Hong ; VanHeyst, Michael D</creatorcontrib><description>Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240725&DB=EPODOC&CC=US&NR=2024246932A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240725&DB=EPODOC&CC=US&NR=2024246932A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Liu, Jian</creatorcontrib><creatorcontrib>Shah, Akshay A</creatorcontrib><creatorcontrib>Cox, Jason M</creatorcontrib><creatorcontrib>Layton, Mark Eric</creatorcontrib><creatorcontrib>Bell, Ian M</creatorcontrib><creatorcontrib>Kelly, III, Michael J</creatorcontrib><creatorcontrib>Arasappan, Ashok</creatorcontrib><creatorcontrib>Liu, Hong</creatorcontrib><creatorcontrib>VanHeyst, Michael D</creatorcontrib><title>ARYL 3-OXOPIPERAZINE CARBOXAMIDES AND HETEROARYL 3-OXOPIPERAZINE CARBOXAMIDES AS NAV1.8 INHIBITORS</title><description>Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZEhyDIr0UTDW9Y_wD_AMcA1yjPL0c1Vwdgxy8o9w9PV0cQ1WcPRzUfBwDXEN8idCbbCCn2OYoZ6Fgqefh6eTZ4h_UDAPA2taYk5xKi-U5mZQdnMNcfbQTS3Ij08tLkhMTs1LLYkPDTYyMDIxMjGzNDZyNDQmThUAwek09A</recordid><startdate>20240725</startdate><enddate>20240725</enddate><creator>Liu, Jian</creator><creator>Shah, Akshay A</creator><creator>Cox, Jason M</creator><creator>Layton, Mark Eric</creator><creator>Bell, Ian M</creator><creator>Kelly, III, Michael J</creator><creator>Arasappan, Ashok</creator><creator>Liu, Hong</creator><creator>VanHeyst, Michael D</creator><scope>EVB</scope></search><sort><creationdate>20240725</creationdate><title>ARYL 3-OXOPIPERAZINE CARBOXAMIDES AND HETEROARYL 3-OXOPIPERAZINE CARBOXAMIDES AS NAV1.8 INHIBITORS</title><author>Liu, Jian ; Shah, Akshay A ; Cox, Jason M ; Layton, Mark Eric ; Bell, Ian M ; Kelly, III, Michael J ; Arasappan, Ashok ; Liu, Hong ; VanHeyst, Michael D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2024246932A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>Liu, Jian</creatorcontrib><creatorcontrib>Shah, Akshay A</creatorcontrib><creatorcontrib>Cox, Jason M</creatorcontrib><creatorcontrib>Layton, Mark Eric</creatorcontrib><creatorcontrib>Bell, Ian M</creatorcontrib><creatorcontrib>Kelly, III, Michael J</creatorcontrib><creatorcontrib>Arasappan, Ashok</creatorcontrib><creatorcontrib>Liu, Hong</creatorcontrib><creatorcontrib>VanHeyst, Michael D</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Liu, Jian</au><au>Shah, Akshay A</au><au>Cox, Jason M</au><au>Layton, Mark Eric</au><au>Bell, Ian M</au><au>Kelly, III, Michael J</au><au>Arasappan, Ashok</au><au>Liu, Hong</au><au>VanHeyst, Michael D</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ARYL 3-OXOPIPERAZINE CARBOXAMIDES AND HETEROARYL 3-OXOPIPERAZINE CARBOXAMIDES AS NAV1.8 INHIBITORS</title><date>2024-07-25</date><risdate>2024</risdate><abstract>Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_US2024246932A1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | ARYL 3-OXOPIPERAZINE CARBOXAMIDES AND HETEROARYL 3-OXOPIPERAZINE CARBOXAMIDES AS NAV1.8 INHIBITORS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T02%3A44%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Liu,%20Jian&rft.date=2024-07-25&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS2024246932A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |