USES OF PYRIMIDOPYRIMIDINONES AS SIK INHIBITORS

The present disclosure provides methods of increasing skin pigmentation in a subject in need thereof using salt-inducible kinase (SIK) inhibitors, such as macrocyclic compounds of Formula (I), bicyclic urea compounds of Formula (II), (III), and (IV), and compounds of Formula (V), (VI), (VI-A), or (V...

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Hauptverfasser:	Gray, Nathanael S, Fisher, David E, Choi, Hwan Geun, Mujahid, Nisma, Murakami, Ryo, Liang, Yanke
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	Gray, Nathanael S Fisher, David E Choi, Hwan Geun Mujahid, Nisma Murakami, Ryo Liang, Yanke
description	The present disclosure provides methods of increasing skin pigmentation in a subject in need thereof using salt-inducible kinase (SIK) inhibitors, such as macrocyclic compounds of Formula (I), bicyclic urea compounds of Formula (II), (III), and (IV), and compounds of Formula (V), (VI), (VI-A), or (VII). Also provided are pharmaceutical compositions, methods, and uses that include or involve a compound described herein.
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title	USES OF PYRIMIDOPYRIMIDINONES AS SIK INHIBITORS
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