INSECT PROTEIN COMPOSITION FOR THE PREVENTION AND TREATMENT OF OSTEARTHRITIS

The invention relates to an insect protein composition for use as a medicament, or for use in a method for the prophylaxis or treatment of inflammation, osteoarthritis, synovial inflammation, synovial macrophage activation, macrophage-induced synovial damage, or low-grade inflammatory disease of a j...

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Hauptverfasser: Tomé, Nuria Martin, Chakraborty, Arpita, Paul, Aman
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creator Tomé, Nuria Martin
Chakraborty, Arpita
Paul, Aman
description The invention relates to an insect protein composition for use as a medicament, or for use in a method for the prophylaxis or treatment of inflammation, osteoarthritis, synovial inflammation, synovial macrophage activation, macrophage-induced synovial damage, or low-grade inflammatory disease of a joint. Typically, the insect is black soldier fly larvae. Typically, the protein is water-soluble protein and/or enzymatically hydrolysed protein. Preferably, the composition comprises glucosamine. As part of the invention, the insect protein composition inhibits and/or prevents macrophage activation, and/or prevents or inhibits macrophage-induced synovial damage, and/or inhibits and/or prevents cell lysis and/or inhibits and/or prevents reactive oxygen species formation by a cell and/or comprises glucosamine. The invention also relates to a food or feed supplement, ingredient or product, comprising the insect protein composition. Furthermore, the invention relates to a non-therapeutic method of prevention against, providing relief from or amelioration of a joint problem in a human subject or an animal such as a horse, a pet such as a dog or a cat, preferably a human subject or a dog, the method comprising orally administering to the human subject or the animal the insect protein composition. The invention also relates to a pharmaceutical composition comprising the insect protein composition, and to the pharmaceutical composition for use as a medicament and for use in the treatment or prevention of osteoarthritis.
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Typically, the insect is black soldier fly larvae. Typically, the protein is water-soluble protein and/or enzymatically hydrolysed protein. Preferably, the composition comprises glucosamine. As part of the invention, the insect protein composition inhibits and/or prevents macrophage activation, and/or prevents or inhibits macrophage-induced synovial damage, and/or inhibits and/or prevents cell lysis and/or inhibits and/or prevents reactive oxygen species formation by a cell and/or comprises glucosamine. The invention also relates to a food or feed supplement, ingredient or product, comprising the insect protein composition. Furthermore, the invention relates to a non-therapeutic method of prevention against, providing relief from or amelioration of a joint problem in a human subject or an animal such as a horse, a pet such as a dog or a cat, preferably a human subject or a dog, the method comprising orally administering to the human subject or the animal the insect protein composition. 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subjects FODDER
FOODS OR FOODSTUFFS
FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT
THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
title INSECT PROTEIN COMPOSITION FOR THE PREVENTION AND TREATMENT OF OSTEARTHRITIS
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