ENGINEERED 3-O-KINASE VARIANTS AND METHODS OF USE

The present invention provides engineered 3′O-kinase polypeptides useful for construction of materials used in template-independent polynucleotide synthesis, as well as compositions and methods of utilizing these engineered polypeptides. The present disclosure also describes one-pot methods for conv...

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Bibliographische Detailangaben
Hauptverfasser: Forgel, Stephanie Marie, Watts, David, Krawczyk, Mikayla, Shoubber, Amani, Provencher, Philip, Vroom, Jonathan, Knight, Anders Matthew, Entwistle, David, Wong, Leland
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention provides engineered 3′O-kinase polypeptides useful for construction of materials used in template-independent polynucleotide synthesis, as well as compositions and methods of utilizing these engineered polypeptides. The present disclosure also describes one-pot methods for conversion of a natural or modified nucleoside to a nucleoside tetraphosphate or NQP.