CHAOTROPES-ASSISTED DEEP IMMUNOSTAINING
The subject invention pertains to the use of chaotropes and a supramolecular system for histochemical staining. The system includes chaotropic ions and chaotropic ion complexing agents that act as molecular hosts to accept chaotropic ions as a molecular guest. The chaotropic ion promotes diffusion o...
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| creator | Yau, Chun Ngo LAI, Hei Ming |
| description | The subject invention pertains to the use of chaotropes and a supramolecular system for histochemical staining. The system includes chaotropic ions and chaotropic ion complexing agents that act as molecular hosts to accept chaotropic ions as a molecular guest. The chaotropic ion promotes diffusion of a probe, such as an antibody into and within a tissue sample with subsequent binding of the guest to the host, or its dilution, to promote association of the antibody with a target antigen and production of an immunostaining or histochemical signal. Alternatively, small-molecule fluorescent probes can act as a molecular guest and complexed by supramolecular host to facilitate its deep penetration. A method for performing histology employs the supramolecular system with a deep homogeneous histochemistry. The method is relatively rapid, scalable, automatable, and cost effective. |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS OF MACROMOLECULAR COMPOUNDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PHYSICS TESTING THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | CHAOTROPES-ASSISTED DEEP IMMUNOSTAINING |
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