QUANTIFICATION OF CELL MIGRATION AND METASTATIC POTENTIAL OF TUMOR CELLS
The present invention relates to a gradient-on-a-chip device for quantification of cell migration and metastatic potential of tumor cells. The device comprises a chip having a chip surface, and a nano gradient layer of nanoparticles provided on the chip surface. The nano gradient layer having a grad...
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| creator | ANDÄNG, Michael SZESZULA, Petra VINCENT, Theresa SUNDH, Patrik HOLMQUIST, Niklas EVENBRATT, Hanne MOBINI, Reza |
| description | The present invention relates to a gradient-on-a-chip device for quantification of cell migration and metastatic potential of tumor cells. The device comprises a chip having a chip surface, and a nano gradient layer of nanoparticles provided on the chip surface. The nano gradient layer having a gradient direction along an axis of an X-Y plane of the chip surface. The device further comprises a biomolecule conjugated to the nanoparticles and a linker conjugated to the nanoparticles, the linker linking together said biomolecule to said nanoparticles. The chip surface has at least one guiding structure arranged to guide the tumor cells in the gradient direction, the guiding structure extending in the gradient direction and delineating a migration corridor comprising the nano gradient layer. |
| format | Patent |
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| subjects | CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS TESTING TRANSPORTING |
| title | QUANTIFICATION OF CELL MIGRATION AND METASTATIC POTENTIAL OF TUMOR CELLS |
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