COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FGF ACTIVITY
The invention features compounds which modulate FGF activity, e.g., by enhancing the binding between FGF-2 and its receptors, e.g., FGF-R1. Also featured is a pharmaceutical composition containing one or more of the compounds, a method of treating an injury or a disease e.g., stroke, congenital hypo...
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| creator | KRAMER, James Bernard CISKE, Fred Lawrence HEIPLE, Paige Elizabeth OLSON, Kirk Lang SKERLJ, Renato HOLT, Melissa Christine CUNY, Gregory D RAY, Soumya FINKLESTEIN, Seth P BARRETT, Stephen Douglas |
| description | The invention features compounds which modulate FGF activity, e.g., by enhancing the binding between FGF-2 and its receptors, e.g., FGF-R1. Also featured is a pharmaceutical composition containing one or more of the compounds, a method of treating an injury or a disease e.g., stroke, congenital hypogonadotropic hypogonadism, and viral infection, and a method of increasing spermatogenesis using the pharmaceutical composition. |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FGF ACTIVITY |
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