COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FGF ACTIVITY

The invention features compounds which modulate FGF activity, e.g., by enhancing the binding between FGF-2 and its receptors, e.g., FGF-R1. Also featured is a pharmaceutical composition containing one or more of the compounds, a method of treating an injury or a disease e.g., stroke, congenital hypo...

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Bibliographische Detailangaben
Hauptverfasser:	KRAMER, James Bernard, CISKE, Fred Lawrence, HEIPLE, Paige Elizabeth, OLSON, Kirk Lang, SKERLJ, Renato, HOLT, Melissa Christine, CUNY, Gregory D, RAY, Soumya, FINKLESTEIN, Seth P, BARRETT, Stephen Douglas
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention features compounds which modulate FGF activity, e.g., by enhancing the binding between FGF-2 and its receptors, e.g., FGF-R1. Also featured is a pharmaceutical composition containing one or more of the compounds, a method of treating an injury or a disease e.g., stroke, congenital hypogonadotropic hypogonadism, and viral infection, and a method of increasing spermatogenesis using the pharmaceutical composition.