BET SUBFAMILY INHIBITORS AND METHODS USING SAME

In one aspect, the present disclosure provides compounds which inhibit bromodomain testis (BRDT). In some embodiments, the compounds inhibit bromodomain-2 of BRDT. In another aspect, the present disclosure provides a method of inhibiting BRDT in a male subject, the method comprising administering to...

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Bibliographische Detailangaben
Hauptverfasser:	Ku, Angela, Young, Damian, Matzuk, Martin, Sharma, Rajesh, Kim, Choel, Chen, Ying-Chu, Anglin, Justin, Ucisik, Melek, Palmer, Stephen, Faver, John, Yu, Zhifeng, Li, Feng
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	In one aspect, the present disclosure provides compounds which inhibit bromodomain testis (BRDT). In some embodiments, the compounds inhibit bromodomain-2 of BRDT. In another aspect, the present disclosure provides a method of inhibiting BRDT in a male subject, the method comprising administering to the male subject a therapeutically effective amount of a compound of the disclosure. In some embodiments, the method provides a contraceptive effect in the male subject.