OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In so...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | Butler, David Charles Donnell Francis, Christopher J Lu, Genliang Meena Verdine, Gregory L Iwamoto, Naoki Zhang, Jason Jingxin Frank-Kamenetsky, Maria David Vargeese, Chandra Divakaramenon, Sethumadhavan Marappan, Subramanian Yang, Hailin |
| description | Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2024117347A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2024117347A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2024117347A13</originalsourceid><addsrcrecordid>eNrjZDDw9_F09_cLdfZx9Q_xdHFVcPb3DfAP9gzx9PcLVnD0c1HwdQ3x8HcJVgjxcA1y9XfjYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXxocFGBkYmhobmxibmjobGxKkCAPEzJ4o</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF</title><source>esp@cenet</source><creator>Butler, David Charles Donnell ; Francis, Christopher J ; Lu, Genliang ; Meena ; Verdine, Gregory L ; Iwamoto, Naoki ; Zhang, Jason Jingxin ; Frank-Kamenetsky, Maria David ; Vargeese, Chandra ; Divakaramenon, Sethumadhavan ; Marappan, Subramanian ; Yang, Hailin</creator><creatorcontrib>Butler, David Charles Donnell ; Francis, Christopher J ; Lu, Genliang ; Meena ; Verdine, Gregory L ; Iwamoto, Naoki ; Zhang, Jason Jingxin ; Frank-Kamenetsky, Maria David ; Vargeese, Chandra ; Divakaramenon, Sethumadhavan ; Marappan, Subramanian ; Yang, Hailin</creatorcontrib><description>Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.</description><language>eng</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; DERIVATIVES THEREOF ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; SUGARS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240411&DB=EPODOC&CC=US&NR=2024117347A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240411&DB=EPODOC&CC=US&NR=2024117347A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Butler, David Charles Donnell</creatorcontrib><creatorcontrib>Francis, Christopher J</creatorcontrib><creatorcontrib>Lu, Genliang</creatorcontrib><creatorcontrib>Meena</creatorcontrib><creatorcontrib>Verdine, Gregory L</creatorcontrib><creatorcontrib>Iwamoto, Naoki</creatorcontrib><creatorcontrib>Zhang, Jason Jingxin</creatorcontrib><creatorcontrib>Frank-Kamenetsky, Maria David</creatorcontrib><creatorcontrib>Vargeese, Chandra</creatorcontrib><creatorcontrib>Divakaramenon, Sethumadhavan</creatorcontrib><creatorcontrib>Marappan, Subramanian</creatorcontrib><creatorcontrib>Yang, Hailin</creatorcontrib><title>OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF</title><description>Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>DERIVATIVES THEREOF</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>SUGARS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDw9_F09_cLdfZx9Q_xdHFVcPb3DfAP9gzx9PcLVnD0c1HwdQ3x8HcJVgjxcA1y9XfjYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXxocFGBkYmhobmxibmjobGxKkCAPEzJ4o</recordid><startdate>20240411</startdate><enddate>20240411</enddate><creator>Butler, David Charles Donnell</creator><creator>Francis, Christopher J</creator><creator>Lu, Genliang</creator><creator>Meena</creator><creator>Verdine, Gregory L</creator><creator>Iwamoto, Naoki</creator><creator>Zhang, Jason Jingxin</creator><creator>Frank-Kamenetsky, Maria David</creator><creator>Vargeese, Chandra</creator><creator>Divakaramenon, Sethumadhavan</creator><creator>Marappan, Subramanian</creator><creator>Yang, Hailin</creator><scope>EVB</scope></search><sort><creationdate>20240411</creationdate><title>OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF</title><author>Butler, David Charles Donnell ; Francis, Christopher J ; Lu, Genliang ; Meena ; Verdine, Gregory L ; Iwamoto, Naoki ; Zhang, Jason Jingxin ; Frank-Kamenetsky, Maria David ; Vargeese, Chandra ; Divakaramenon, Sethumadhavan ; Marappan, Subramanian ; Yang, Hailin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2024117347A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2024</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>DERIVATIVES THEREOF</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>SUGARS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>Butler, David Charles Donnell</creatorcontrib><creatorcontrib>Francis, Christopher J</creatorcontrib><creatorcontrib>Lu, Genliang</creatorcontrib><creatorcontrib>Meena</creatorcontrib><creatorcontrib>Verdine, Gregory L</creatorcontrib><creatorcontrib>Iwamoto, Naoki</creatorcontrib><creatorcontrib>Zhang, Jason Jingxin</creatorcontrib><creatorcontrib>Frank-Kamenetsky, Maria David</creatorcontrib><creatorcontrib>Vargeese, Chandra</creatorcontrib><creatorcontrib>Divakaramenon, Sethumadhavan</creatorcontrib><creatorcontrib>Marappan, Subramanian</creatorcontrib><creatorcontrib>Yang, Hailin</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Butler, David Charles Donnell</au><au>Francis, Christopher J</au><au>Lu, Genliang</au><au>Meena</au><au>Verdine, Gregory L</au><au>Iwamoto, Naoki</au><au>Zhang, Jason Jingxin</au><au>Frank-Kamenetsky, Maria David</au><au>Vargeese, Chandra</au><au>Divakaramenon, Sethumadhavan</au><au>Marappan, Subramanian</au><au>Yang, Hailin</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF</title><date>2024-04-11</date><risdate>2024</risdate><abstract>Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_US2024117347A1 |
| source | esp@cenet |
| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS VINEGAR WINE |
| title | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T19%3A40%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Butler,%20David%20Charles%20Donnell&rft.date=2024-04-11&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS2024117347A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |