Method of Obtaining Betulin as an Adjuvant in a Vaccine Against Coronavirus SARS-COV-2
The invention relates to biotechnology, and specifically to a method for creating the adjuvant betulin, suitable for preparing a vaccine against coronavirus SARS-CoV-2. The method consists in sterilizing filtration of a solution of betulin in tetrahydrofuran through a nylon membrane with a pore diam...
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| creator | FLOLOVA, Maria Evgenievna VAKHRUSHEVA, Anna Vladimirovna KUDRYAVTSEV, Alexander Viktorovich ISAEV, Artur Alexandrovich KRASILNIKOV, Igor Viktorovich IVANOV, Alexander Viktorovich |
| description | The invention relates to biotechnology, and specifically to a method for creating the adjuvant betulin, suitable for preparing a vaccine against coronavirus SARS-CoV-2. The method consists in sterilizing filtration of a solution of betulin in tetrahydrofuran through a nylon membrane with a pore diameter of 0.22 μm, decreasing the tetrahydrofuran content by adding a 25-fold volume of sterile 0.01 M tris-buffer (pH 9.0+0.1), and subsequently homogenizing by ultrasound until a homogeneous suspension results, forming spherical amorphous homogeneous particles suitable for binding proteins of the SARS-CoV-2 virus. The proposed technique makes it possible to produce betulin with high sterility and immunogenicity, which improves the quality of the vaccine against the coronavirus. |
| format | Patent |
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| title | Method of Obtaining Betulin as an Adjuvant in a Vaccine Against Coronavirus SARS-COV-2 |
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