USING MINIVECTORS TO TREAT IDIOPATHIC PULMONARY FIBROSIS

USING MINIVECTORS TO TREAT IDIOPATHIC PULMONARY FIBROSIS

MiniVectors and compositions containing MiniVectors that target genes implicated in IPF selected from CDH11, STAT3, STAT6, FoxM1, MDM2, TGFβ, SMAD, PDGFA, or TLR4 and/or increase intracellular levels of reduced glutathione, relaxin, and p53, are provided, along with uses in the treatment of idiopath...

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Bibliographische Detailangaben
Hauptverfasser: AREVALO-SOLIZ, Lirio Milenka, FOGG, Jonathan Marcus, COKER, Christopher E, ZECHIEDRICH, E. Lynn, CATANESE, JR., Daniel James
Format: Patent
Sprache:eng
Schlagworte:
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BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
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Zusammenfassung:MiniVectors and compositions containing MiniVectors that target genes implicated in IPF selected from CDH11, STAT3, STAT6, FoxM1, MDM2, TGFβ, SMAD, PDGFA, or TLR4 and/or increase intracellular levels of reduced glutathione, relaxin, and p53, are provided, along with uses in the treatment of idiopathic pulmonary fibrosis.