ANTIBODY BINDING TO FCRN FOR TREATING AUTOIMMUNE DISEASES
The present disclosure relates to an isolated anti-FcRN antibody, which is an antibody binding to FcRN (stands for neonatal Fc receptor, also called FcRP, FcRB or Brambell receptor) that is a receptor with a high affinity for IgG or a fragment thereof, a method of preparing thereof, a composition fo...
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| creator | KIM, Eun Sun YOO, Tae Hyoung KIM, Min Sun PARK, Seung Kook YONG, Hae-Young SHIN, Dongok AHN, Hyea Kyung JEONG, Jae Kap KIM, Sung Wuk SONG, Yeon Jung |
| description | The present disclosure relates to an isolated anti-FcRN antibody, which is an antibody binding to FcRN (stands for neonatal Fc receptor, also called FcRP, FcRB or Brambell receptor) that is a receptor with a high affinity for IgG or a fragment thereof, a method of preparing thereof, a composition for treating autoimmune disease, which comprises the antibody, and a method of treating and diagnosing autoimmunre diseases using the antibody. The FcRn-specific antibody according to the present disclosure binds to FcRn non-competitively with IgG to reduce serum pathogenic auto-antibody levels, and thus can be used for the treatment of autoimmune diseases. |
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| subjects | CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING |
| title | ANTIBODY BINDING TO FCRN FOR TREATING AUTOIMMUNE DISEASES |
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