HETEROARYL DIAMIDE IRE1/XBP1s ACTIVATORS

HETEROARYL DIAMIDE IRE1/XBP1s ACTIVATORS

Provided herein are compounds that activate IRE1/XBP1s, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject having a disease or disorder that may be ameliorated by increa...

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Hauptverfasser: Guerrero, Adrian Marco, Petrassi, Hank Michael James, Kelly, Jeffery W, Lee, Kyunga, Tait, Bradley Dean, Wiseman, R. Luke, Labaudiniere, Richard F
Format: Patent
Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator Guerrero, Adrian Marco
Petrassi, Hank Michael James
Kelly, Jeffery W
Lee, Kyunga
Tait, Bradley Dean
Wiseman, R. Luke
Labaudiniere, Richard F
description Provided herein are compounds that activate IRE1/XBP1s, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject having a disease or disorder that may be ameliorated by increasing IRE1/XBP1s activity.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title HETEROARYL DIAMIDE IRE1/XBP1s ACTIVATORS
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