POLYMORPHS OF THE HYDROCHLORIDE SALT OF LINAPRAZAN GLURATE

POLYMORPHS OF THE HYDROCHLORIDE SALT OF LINAPRAZAN GLURATE

The present invention relates to polymorphs of the hydrochloride salt of 5-{2-[({8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-yl}carbonyl)-amino]ethoxy}-5-oxopentanoic acid (linaprazan glurate), more specifically Form 1 and Form 2 of the HCl salt of linaprazan glurate. The inve...

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Hauptverfasser: Larsson, Thomas, Jarring, Kjell, LIN, Xingbang, WANG, Dan, Hillgren, Mikael
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator Larsson, Thomas
Jarring, Kjell
LIN, Xingbang
WANG, Dan
Hillgren, Mikael
description The present invention relates to polymorphs of the hydrochloride salt of 5-{2-[({8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-yl}carbonyl)-amino]ethoxy}-5-oxopentanoic acid (linaprazan glurate), more specifically Form 1 and Form 2 of the HCl salt of linaprazan glurate. The invention also relates to a process for the preparation of such polymorphs, to pharmaceutical compositions comprising such polymorphs, and to the use of these polymorphs in the treatment or prevention of gastrointestinal inflammatory diseases or gastric acid related diseases, in particular erosive gastroesophageal reflux disease (eGERD).
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title POLYMORPHS OF THE HYDROCHLORIDE SALT OF LINAPRAZAN GLURATE
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