ANHYDROUS SODIUM THIOSULFATE AND FORMULATIONS THEREOF

ANHYDROUS SODIUM THIOSULFATE AND FORMULATIONS THEREOF

Described herein is anhydrous sodium thiosulfate, methods for synthesizing anhydrous sodium thiosulfate, pharmaceutical compositions thereof, and methods of treating ototoxicity. Anhydrous sodium thiosulfate is synthesized from sodium sulfite, sulfur, and cetylpyridinium chloride. The anhydrous sodi...

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Hauptverfasser: Lovelace, Thomas Claiborne, Moore, III, Joseph Alexander, Lee, Christopher McKinnon, Kirschner, Daniel Logan
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator Lovelace, Thomas Claiborne
Moore, III, Joseph Alexander
Lee, Christopher McKinnon
Kirschner, Daniel Logan
description Described herein is anhydrous sodium thiosulfate, methods for synthesizing anhydrous sodium thiosulfate, pharmaceutical compositions thereof, and methods of treating ototoxicity. Anhydrous sodium thiosulfate is synthesized from sodium sulfite, sulfur, and cetylpyridinium chloride. The anhydrous sodium thiosulfate is formulated into a pharmaceutical composition comprising a buffer and solvent. These compositions are useful for eliminating or reducing ototoxicity in pediatric patients receiving platinum-based chemotherapeutics.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title ANHYDROUS SODIUM THIOSULFATE AND FORMULATIONS THEREOF
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