ENANTIOSELECTIVE ALKENYLATION OF ALDEHYDES

ENANTIOSELECTIVE ALKENYLATION OF ALDEHYDES

Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound IA, wherein R1 is described herein. Compound IA can be useful in synthesizing compound A1, or a salt or solvate thereof, and compo...

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Bibliographische Detailangaben
Hauptverfasser: CORBETT, MICHAEL T, LANGILLE, NEIL F, PROFETA, ROBERTO, SMITH, AUSTIN G, BAUCOM, KYLE D, ROTHELI, ANDREAS RENE, CUI, SHENG
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound IA, wherein R1 is described herein. Compound IA can be useful in synthesizing compound A1, or a salt or solvate thereof, and compound A2, or a salt of solvate thereof.