CORONAVIRUS INFECTIOUS DISEASE COVID-19 THERAPEUTIC PROTEINS CTP ALPHA, CTP BETA, CTP GAMMA, CTP DELTA, AND USES THEREOF
The present invention relates to coronavirus infectious disease COVID-19 therapeutic proteins CTP alpha, CTP beta, CTP gamma, CTP delta, and uses thereof. Compared to a known peptide (P6) which mimics the binding site of a receptor binding domain (RBD) of SARS-CoV and angiotensin-converting enzyme 2...
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| creator | KIM, Min Gi LEE, Ae Ree MIN, Ga Hee KANG, Mooseok JI, Sang Ho CHOI, Min Jee KIM, Sang Yeol LEE, Young-Ho CHOI, Jae Seok CHOI, Seong Kyoon KIM, Hee Yeon KIM, Hyo Eun CHANG, Iksoo LEE, Juhwan PARK, Song KWON, Wookbong YU, Woo Kyung PARK, Seongjun SEO, Souk LEE, Kyung Eun |
| description | The present invention relates to coronavirus infectious disease COVID-19 therapeutic proteins CTP alpha, CTP beta, CTP gamma, CTP delta, and uses thereof. Compared to a known peptide (P6) which mimics the binding site of a receptor binding domain (RBD) of SARS-CoV and angiotensin-converting enzyme 2 (ACE2), the therapeutic proteins CTP alpha, CTP beta, CTP gamma, and CTP delta according to the present invention comprise a novel part obtained by adding a novel sequence of amino acids, wherein the interaction of atoms constituting the amino acids has been fundamentally designed in order to strengthen the binding of SARS-CoV2 to a novel epitope of RBD. The present invention provides therapeutic proteins CTP alpha, CTP beta, CTP gamma, and CTP delta having a novel design and capable of binding more strongly than known peptides due to being creative designs of the extended therapeutic proteins CTP alpha, CTP beta, CTP gamma, and CTP delta, wherein the therapeutic proteins can additionally interact with charged amino acids of D420 and K458 on the rear side of the conventional binding interface between RBD and hACE2 or additionally interact with charged amino acids such as R454, K458, D467, and E471. The therapeutic proteins CTP alpha, CTP beta, CTP gamma, and CTP delta according to the present invention have the potential of being highly applicable as COVID-19 therapeutic agents. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2023406886A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2023406886A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2023406886A13</originalsourceid><addsrcrecordid>eNqNzL0KwjAUBeAuDqK-wwVXC_2RUsdrcmsDbRLy07UUiZNooQ4-vlr6AE7n43A46-jNlFESO2G8BSErYk6oL7mwhJaAqU7wOD2Bq8mgJu8EA22UIyEtMKcBG13jYeaZ3KILtu1CTs2vRcnBW7LzEalqG61uw30KuyU30b4ix-o4jM8-TONwDY_w6r3Nkiw_JkVZFpjm_60-L3Y6LA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>CORONAVIRUS INFECTIOUS DISEASE COVID-19 THERAPEUTIC PROTEINS CTP ALPHA, CTP BETA, CTP GAMMA, CTP DELTA, AND USES THEREOF</title><source>esp@cenet</source><creator>KIM, Min Gi ; LEE, Ae Ree ; MIN, Ga Hee ; KANG, Mooseok ; JI, Sang Ho ; CHOI, Min Jee ; KIM, Sang Yeol ; LEE, Young-Ho ; CHOI, Jae Seok ; CHOI, Seong Kyoon ; KIM, Hee Yeon ; KIM, Hyo Eun ; CHANG, Iksoo ; LEE, Juhwan ; PARK, Song ; KWON, Wookbong ; YU, Woo Kyung ; PARK, Seongjun ; SEO, Souk ; LEE, Kyung Eun</creator><creatorcontrib>KIM, Min Gi ; LEE, Ae Ree ; MIN, Ga Hee ; KANG, Mooseok ; JI, Sang Ho ; CHOI, Min Jee ; KIM, Sang Yeol ; LEE, Young-Ho ; CHOI, Jae Seok ; CHOI, Seong Kyoon ; KIM, Hee Yeon ; KIM, Hyo Eun ; CHANG, Iksoo ; LEE, Juhwan ; PARK, Song ; KWON, Wookbong ; YU, Woo Kyung ; PARK, Seongjun ; SEO, Souk ; LEE, Kyung Eun</creatorcontrib><description>The present invention relates to coronavirus infectious disease COVID-19 therapeutic proteins CTP alpha, CTP beta, CTP gamma, CTP delta, and uses thereof. Compared to a known peptide (P6) which mimics the binding site of a receptor binding domain (RBD) of SARS-CoV and angiotensin-converting enzyme 2 (ACE2), the therapeutic proteins CTP alpha, CTP beta, CTP gamma, and CTP delta according to the present invention comprise a novel part obtained by adding a novel sequence of amino acids, wherein the interaction of atoms constituting the amino acids has been fundamentally designed in order to strengthen the binding of SARS-CoV2 to a novel epitope of RBD. The present invention provides therapeutic proteins CTP alpha, CTP beta, CTP gamma, and CTP delta having a novel design and capable of binding more strongly than known peptides due to being creative designs of the extended therapeutic proteins CTP alpha, CTP beta, CTP gamma, and CTP delta, wherein the therapeutic proteins can additionally interact with charged amino acids of D420 and K458 on the rear side of the conventional binding interface between RBD and hACE2 or additionally interact with charged amino acids such as R454, K458, D467, and E471. The therapeutic proteins CTP alpha, CTP beta, CTP gamma, and CTP delta according to the present invention have the potential of being highly applicable as COVID-19 therapeutic agents.</description><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; TESTING</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231221&DB=EPODOC&CC=US&NR=2023406886A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231221&DB=EPODOC&CC=US&NR=2023406886A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KIM, Min Gi</creatorcontrib><creatorcontrib>LEE, Ae Ree</creatorcontrib><creatorcontrib>MIN, Ga Hee</creatorcontrib><creatorcontrib>KANG, Mooseok</creatorcontrib><creatorcontrib>JI, Sang Ho</creatorcontrib><creatorcontrib>CHOI, Min Jee</creatorcontrib><creatorcontrib>KIM, Sang Yeol</creatorcontrib><creatorcontrib>LEE, Young-Ho</creatorcontrib><creatorcontrib>CHOI, Jae Seok</creatorcontrib><creatorcontrib>CHOI, Seong Kyoon</creatorcontrib><creatorcontrib>KIM, Hee Yeon</creatorcontrib><creatorcontrib>KIM, Hyo Eun</creatorcontrib><creatorcontrib>CHANG, Iksoo</creatorcontrib><creatorcontrib>LEE, Juhwan</creatorcontrib><creatorcontrib>PARK, Song</creatorcontrib><creatorcontrib>KWON, Wookbong</creatorcontrib><creatorcontrib>YU, Woo Kyung</creatorcontrib><creatorcontrib>PARK, Seongjun</creatorcontrib><creatorcontrib>SEO, Souk</creatorcontrib><creatorcontrib>LEE, Kyung Eun</creatorcontrib><title>CORONAVIRUS INFECTIOUS DISEASE COVID-19 THERAPEUTIC PROTEINS CTP ALPHA, CTP BETA, CTP GAMMA, CTP DELTA, AND USES THEREOF</title><description>The present invention relates to coronavirus infectious disease COVID-19 therapeutic proteins CTP alpha, CTP beta, CTP gamma, CTP delta, and uses thereof. Compared to a known peptide (P6) which mimics the binding site of a receptor binding domain (RBD) of SARS-CoV and angiotensin-converting enzyme 2 (ACE2), the therapeutic proteins CTP alpha, CTP beta, CTP gamma, and CTP delta according to the present invention comprise a novel part obtained by adding a novel sequence of amino acids, wherein the interaction of atoms constituting the amino acids has been fundamentally designed in order to strengthen the binding of SARS-CoV2 to a novel epitope of RBD. The present invention provides therapeutic proteins CTP alpha, CTP beta, CTP gamma, and CTP delta having a novel design and capable of binding more strongly than known peptides due to being creative designs of the extended therapeutic proteins CTP alpha, CTP beta, CTP gamma, and CTP delta, wherein the therapeutic proteins can additionally interact with charged amino acids of D420 and K458 on the rear side of the conventional binding interface between RBD and hACE2 or additionally interact with charged amino acids such as R454, K458, D467, and E471. The therapeutic proteins CTP alpha, CTP beta, CTP gamma, and CTP delta according to the present invention have the potential of being highly applicable as COVID-19 therapeutic agents.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNzL0KwjAUBeAuDqK-wwVXC_2RUsdrcmsDbRLy07UUiZNooQ4-vlr6AE7n43A46-jNlFESO2G8BSErYk6oL7mwhJaAqU7wOD2Bq8mgJu8EA22UIyEtMKcBG13jYeaZ3KILtu1CTs2vRcnBW7LzEalqG61uw30KuyU30b4ix-o4jM8-TONwDY_w6r3Nkiw_JkVZFpjm_60-L3Y6LA</recordid><startdate>20231221</startdate><enddate>20231221</enddate><creator>KIM, Min Gi</creator><creator>LEE, Ae Ree</creator><creator>MIN, Ga Hee</creator><creator>KANG, Mooseok</creator><creator>JI, Sang Ho</creator><creator>CHOI, Min Jee</creator><creator>KIM, Sang Yeol</creator><creator>LEE, Young-Ho</creator><creator>CHOI, Jae Seok</creator><creator>CHOI, Seong Kyoon</creator><creator>KIM, Hee Yeon</creator><creator>KIM, Hyo Eun</creator><creator>CHANG, Iksoo</creator><creator>LEE, Juhwan</creator><creator>PARK, Song</creator><creator>KWON, Wookbong</creator><creator>YU, Woo Kyung</creator><creator>PARK, Seongjun</creator><creator>SEO, Souk</creator><creator>LEE, Kyung Eun</creator><scope>EVB</scope></search><sort><creationdate>20231221</creationdate><title>CORONAVIRUS INFECTIOUS DISEASE COVID-19 THERAPEUTIC PROTEINS CTP ALPHA, CTP BETA, CTP GAMMA, CTP DELTA, AND USES THEREOF</title><author>KIM, Min Gi ; LEE, Ae Ree ; MIN, Ga Hee ; KANG, Mooseok ; JI, Sang Ho ; CHOI, Min Jee ; KIM, Sang Yeol ; LEE, Young-Ho ; CHOI, Jae Seok ; CHOI, Seong Kyoon ; KIM, Hee Yeon ; KIM, Hyo Eun ; CHANG, Iksoo ; LEE, Juhwan ; PARK, Song ; KWON, Wookbong ; YU, Woo Kyung ; PARK, Seongjun ; SEO, Souk ; LEE, Kyung Eun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2023406886A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>KIM, Min Gi</creatorcontrib><creatorcontrib>LEE, Ae Ree</creatorcontrib><creatorcontrib>MIN, Ga Hee</creatorcontrib><creatorcontrib>KANG, Mooseok</creatorcontrib><creatorcontrib>JI, Sang Ho</creatorcontrib><creatorcontrib>CHOI, Min Jee</creatorcontrib><creatorcontrib>KIM, Sang Yeol</creatorcontrib><creatorcontrib>LEE, Young-Ho</creatorcontrib><creatorcontrib>CHOI, Jae Seok</creatorcontrib><creatorcontrib>CHOI, Seong Kyoon</creatorcontrib><creatorcontrib>KIM, Hee Yeon</creatorcontrib><creatorcontrib>KIM, Hyo Eun</creatorcontrib><creatorcontrib>CHANG, Iksoo</creatorcontrib><creatorcontrib>LEE, Juhwan</creatorcontrib><creatorcontrib>PARK, Song</creatorcontrib><creatorcontrib>KWON, Wookbong</creatorcontrib><creatorcontrib>YU, Woo Kyung</creatorcontrib><creatorcontrib>PARK, Seongjun</creatorcontrib><creatorcontrib>SEO, Souk</creatorcontrib><creatorcontrib>LEE, Kyung Eun</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KIM, Min Gi</au><au>LEE, Ae Ree</au><au>MIN, Ga Hee</au><au>KANG, Mooseok</au><au>JI, Sang Ho</au><au>CHOI, Min Jee</au><au>KIM, Sang Yeol</au><au>LEE, Young-Ho</au><au>CHOI, Jae Seok</au><au>CHOI, Seong Kyoon</au><au>KIM, Hee Yeon</au><au>KIM, Hyo Eun</au><au>CHANG, Iksoo</au><au>LEE, Juhwan</au><au>PARK, Song</au><au>KWON, Wookbong</au><au>YU, Woo Kyung</au><au>PARK, Seongjun</au><au>SEO, Souk</au><au>LEE, Kyung Eun</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CORONAVIRUS INFECTIOUS DISEASE COVID-19 THERAPEUTIC PROTEINS CTP ALPHA, CTP BETA, CTP GAMMA, CTP DELTA, AND USES THEREOF</title><date>2023-12-21</date><risdate>2023</risdate><abstract>The present invention relates to coronavirus infectious disease COVID-19 therapeutic proteins CTP alpha, CTP beta, CTP gamma, CTP delta, and uses thereof. Compared to a known peptide (P6) which mimics the binding site of a receptor binding domain (RBD) of SARS-CoV and angiotensin-converting enzyme 2 (ACE2), the therapeutic proteins CTP alpha, CTP beta, CTP gamma, and CTP delta according to the present invention comprise a novel part obtained by adding a novel sequence of amino acids, wherein the interaction of atoms constituting the amino acids has been fundamentally designed in order to strengthen the binding of SARS-CoV2 to a novel epitope of RBD. The present invention provides therapeutic proteins CTP alpha, CTP beta, CTP gamma, and CTP delta having a novel design and capable of binding more strongly than known peptides due to being creative designs of the extended therapeutic proteins CTP alpha, CTP beta, CTP gamma, and CTP delta, wherein the therapeutic proteins can additionally interact with charged amino acids of D420 and K458 on the rear side of the conventional binding interface between RBD and hACE2 or additionally interact with charged amino acids such as R454, K458, D467, and E471. The therapeutic proteins CTP alpha, CTP beta, CTP gamma, and CTP delta according to the present invention have the potential of being highly applicable as COVID-19 therapeutic agents.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING |
| title | CORONAVIRUS INFECTIOUS DISEASE COVID-19 THERAPEUTIC PROTEINS CTP ALPHA, CTP BETA, CTP GAMMA, CTP DELTA, AND USES THEREOF |
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