CYCLIC PEPTIDES FOR TRAPPING INTERLEUKIN-1 BETA
Provided are compounds of the Formula (I), or their pharmaceutically acceptable salts, wherein X1, X2, X3, A1, A2, R1-R7, R8a, R8b, R9a, R9b, R10 and R11 are as herein described.can trap IL-1β and are expected to have utility as therapeutic agents, for example, for treating cardiovascular disease an...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | Hanisak, Jennifer Jayne, Charles Lee Feng, Danqing Guo, Zhuyan Plummer, Christopher W Kekec, Ahmet Hickey, Jennifer L Pavone, Francesca Colarusso, Stefania Lo, Michael Man-Chu Nizi, Emanuela Yousif, Ali Munaim Bianchi, Elisabetta Cruz, Faben A |
| description | Provided are compounds of the Formula (I), or their pharmaceutically acceptable salts, wherein X1, X2, X3, A1, A2, R1-R7, R8a, R8b, R9a, R9b, R10 and R11 are as herein described.can trap IL-1β and are expected to have utility as therapeutic agents, for example, for treating cardiovascular disease and inflammatory disorders. The disclosure also provides pharmaceutical compositions which comprise the compounds disclosed herein or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cardiovascular disease and inflammatory disorders and for preparing pharmaceuticals for this purpose. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2023406885A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2023406885A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2023406885A13</originalsourceid><addsrcrecordid>eNrjZNB3jnT28XRWCHANCPF0cQ1WcPMPUggJcgwI8PRzV_D0C3EN8nEN9fb00zVUcHINceRhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfGhwUYGRsYmBmYWFqaOhsbEqQIAlTom2w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>CYCLIC PEPTIDES FOR TRAPPING INTERLEUKIN-1 BETA</title><source>esp@cenet</source><creator>Hanisak, Jennifer ; Jayne, Charles Lee ; Feng, Danqing ; Guo, Zhuyan ; Plummer, Christopher W ; Kekec, Ahmet ; Hickey, Jennifer L ; Pavone, Francesca ; Colarusso, Stefania ; Lo, Michael Man-Chu ; Nizi, Emanuela ; Yousif, Ali Munaim ; Bianchi, Elisabetta ; Cruz, Faben A</creator><creatorcontrib>Hanisak, Jennifer ; Jayne, Charles Lee ; Feng, Danqing ; Guo, Zhuyan ; Plummer, Christopher W ; Kekec, Ahmet ; Hickey, Jennifer L ; Pavone, Francesca ; Colarusso, Stefania ; Lo, Michael Man-Chu ; Nizi, Emanuela ; Yousif, Ali Munaim ; Bianchi, Elisabetta ; Cruz, Faben A</creatorcontrib><description>Provided are compounds of the Formula (I), or their pharmaceutically acceptable salts, wherein X1, X2, X3, A1, A2, R1-R7, R8a, R8b, R9a, R9b, R10 and R11 are as herein described.can trap IL-1β and are expected to have utility as therapeutic agents, for example, for treating cardiovascular disease and inflammatory disorders. The disclosure also provides pharmaceutical compositions which comprise the compounds disclosed herein or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cardiovascular disease and inflammatory disorders and for preparing pharmaceuticals for this purpose.</description><language>eng</language><subject>CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231221&DB=EPODOC&CC=US&NR=2023406885A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231221&DB=EPODOC&CC=US&NR=2023406885A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Hanisak, Jennifer</creatorcontrib><creatorcontrib>Jayne, Charles Lee</creatorcontrib><creatorcontrib>Feng, Danqing</creatorcontrib><creatorcontrib>Guo, Zhuyan</creatorcontrib><creatorcontrib>Plummer, Christopher W</creatorcontrib><creatorcontrib>Kekec, Ahmet</creatorcontrib><creatorcontrib>Hickey, Jennifer L</creatorcontrib><creatorcontrib>Pavone, Francesca</creatorcontrib><creatorcontrib>Colarusso, Stefania</creatorcontrib><creatorcontrib>Lo, Michael Man-Chu</creatorcontrib><creatorcontrib>Nizi, Emanuela</creatorcontrib><creatorcontrib>Yousif, Ali Munaim</creatorcontrib><creatorcontrib>Bianchi, Elisabetta</creatorcontrib><creatorcontrib>Cruz, Faben A</creatorcontrib><title>CYCLIC PEPTIDES FOR TRAPPING INTERLEUKIN-1 BETA</title><description>Provided are compounds of the Formula (I), or their pharmaceutically acceptable salts, wherein X1, X2, X3, A1, A2, R1-R7, R8a, R8b, R9a, R9b, R10 and R11 are as herein described.can trap IL-1β and are expected to have utility as therapeutic agents, for example, for treating cardiovascular disease and inflammatory disorders. The disclosure also provides pharmaceutical compositions which comprise the compounds disclosed herein or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cardiovascular disease and inflammatory disorders and for preparing pharmaceuticals for this purpose.</description><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB3jnT28XRWCHANCPF0cQ1WcPMPUggJcgwI8PRzV_D0C3EN8nEN9fb00zVUcHINceRhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfGhwUYGRsYmBmYWFqaOhsbEqQIAlTom2w</recordid><startdate>20231221</startdate><enddate>20231221</enddate><creator>Hanisak, Jennifer</creator><creator>Jayne, Charles Lee</creator><creator>Feng, Danqing</creator><creator>Guo, Zhuyan</creator><creator>Plummer, Christopher W</creator><creator>Kekec, Ahmet</creator><creator>Hickey, Jennifer L</creator><creator>Pavone, Francesca</creator><creator>Colarusso, Stefania</creator><creator>Lo, Michael Man-Chu</creator><creator>Nizi, Emanuela</creator><creator>Yousif, Ali Munaim</creator><creator>Bianchi, Elisabetta</creator><creator>Cruz, Faben A</creator><scope>EVB</scope></search><sort><creationdate>20231221</creationdate><title>CYCLIC PEPTIDES FOR TRAPPING INTERLEUKIN-1 BETA</title><author>Hanisak, Jennifer ; Jayne, Charles Lee ; Feng, Danqing ; Guo, Zhuyan ; Plummer, Christopher W ; Kekec, Ahmet ; Hickey, Jennifer L ; Pavone, Francesca ; Colarusso, Stefania ; Lo, Michael Man-Chu ; Nizi, Emanuela ; Yousif, Ali Munaim ; Bianchi, Elisabetta ; Cruz, Faben A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2023406885A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><toplevel>online_resources</toplevel><creatorcontrib>Hanisak, Jennifer</creatorcontrib><creatorcontrib>Jayne, Charles Lee</creatorcontrib><creatorcontrib>Feng, Danqing</creatorcontrib><creatorcontrib>Guo, Zhuyan</creatorcontrib><creatorcontrib>Plummer, Christopher W</creatorcontrib><creatorcontrib>Kekec, Ahmet</creatorcontrib><creatorcontrib>Hickey, Jennifer L</creatorcontrib><creatorcontrib>Pavone, Francesca</creatorcontrib><creatorcontrib>Colarusso, Stefania</creatorcontrib><creatorcontrib>Lo, Michael Man-Chu</creatorcontrib><creatorcontrib>Nizi, Emanuela</creatorcontrib><creatorcontrib>Yousif, Ali Munaim</creatorcontrib><creatorcontrib>Bianchi, Elisabetta</creatorcontrib><creatorcontrib>Cruz, Faben A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Hanisak, Jennifer</au><au>Jayne, Charles Lee</au><au>Feng, Danqing</au><au>Guo, Zhuyan</au><au>Plummer, Christopher W</au><au>Kekec, Ahmet</au><au>Hickey, Jennifer L</au><au>Pavone, Francesca</au><au>Colarusso, Stefania</au><au>Lo, Michael Man-Chu</au><au>Nizi, Emanuela</au><au>Yousif, Ali Munaim</au><au>Bianchi, Elisabetta</au><au>Cruz, Faben A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CYCLIC PEPTIDES FOR TRAPPING INTERLEUKIN-1 BETA</title><date>2023-12-21</date><risdate>2023</risdate><abstract>Provided are compounds of the Formula (I), or their pharmaceutically acceptable salts, wherein X1, X2, X3, A1, A2, R1-R7, R8a, R8b, R9a, R9b, R10 and R11 are as herein described.can trap IL-1β and are expected to have utility as therapeutic agents, for example, for treating cardiovascular disease and inflammatory disorders. The disclosure also provides pharmaceutical compositions which comprise the compounds disclosed herein or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cardiovascular disease and inflammatory disorders and for preparing pharmaceuticals for this purpose.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_US2023406885A1 |
| source | esp@cenet |
| subjects | CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES |
| title | CYCLIC PEPTIDES FOR TRAPPING INTERLEUKIN-1 BETA |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T04%3A23%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Hanisak,%20Jennifer&rft.date=2023-12-21&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS2023406885A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |