PROTEOGLYCAN CONJUGATE AND APPLICATION THEREOF

Provided is a tetanus toxin protein variant, the tetanus toxin protein variant comprising a C fragment of the tetanus toxin protein and a partial fragment of a translocation region of the tetanus toxin protein. Further provided is a proteoglycan conjugate, the proteoglycan conjugate comprising a pol...

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Hauptverfasser: XIA, Qingfeng, CHEN, Huagen, XIONG, Xishuang, WANG, Juanjuan, LIU, Chang, SHEN, Enhua, LI, Ying, ZHU, Xianchao, WANG, Zhu, MAO, Yizhi
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creator XIA, Qingfeng
CHEN, Huagen
XIONG, Xishuang
WANG, Juanjuan
LIU, Chang
SHEN, Enhua
LI, Ying
ZHU, Xianchao
WANG, Zhu
MAO, Yizhi
description Provided is a tetanus toxin protein variant, the tetanus toxin protein variant comprising a C fragment of the tetanus toxin protein and a partial fragment of a translocation region of the tetanus toxin protein. Further provided is a proteoglycan conjugate, the proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein. Also provided is a method for improving immunogenicity, the method comprising the following steps: providing a proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title PROTEOGLYCAN CONJUGATE AND APPLICATION THEREOF
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