VIA CYCLOADDITION BILATERALLY FUNCTIONALIZED ANTIBODIES

VIA CYCLOADDITION BILATERALLY FUNCTIONALIZED ANTIBODIES

The present invention provides antibody-payload conjugates having a payload-to-antibody ratio of 1. The antibody-payload conjugate having structure (1): wherein:a, b and c are each independently 0 or 1;L1, L2 and L3 are linkers;D is a payload;BM is a branching moiety;Z are connecting groups obtainab...

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Hauptverfasser: WIJDEVEN, Maria Antonia, VAN DELFT, Floris Louis, POPAL, Sorraya, HOOGENBOOM, Jorin, VAN SCHAIK, Arnoldus Jacobus, VAN BERKEL, Sander Sebastiaan, VAN GEEL, Remon, DE BEVER, Laureen
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Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator WIJDEVEN, Maria Antonia
VAN DELFT, Floris Louis
POPAL, Sorraya
HOOGENBOOM, Jorin
VAN SCHAIK, Arnoldus Jacobus
VAN BERKEL, Sander Sebastiaan
VAN GEEL, Remon
DE BEVER, Laureen
description The present invention provides antibody-payload conjugates having a payload-to-antibody ratio of 1. The antibody-payload conjugate having structure (1): wherein:a, b and c are each independently 0 or 1;L1, L2 and L3 are linkers;D is a payload;BM is a branching moiety;Z are connecting groups obtainable by a cycloaddition reaction.The invention further provides a method for preparing the antibody-payload conjugate according to the invention, an intermediate compound in that preparation method, and medical uses of the antibody-payload conjugate according to the invention.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title VIA CYCLOADDITION BILATERALLY FUNCTIONALIZED ANTIBODIES
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