Negative Allosteric Modulation of GluN3-Containing N-Methyl-D-Aspartate Receptors

Disclosed are negative allosteric modulators of GluN3-containing NMDA receptors. In general, these compounds are highly selective for GluN3 (such as GluN3A and/or GluN3B) over GluN1 and/or GluN2. They can function as non-competitive antagonists with activity that is independent of membrane potential...

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Bibliographische Detailangaben

Hauptverfasser:	Yuan, Hongjie, McCallum, Adam, Liotta, Dennis C, Epplin, Matthew, Jacobs, Leon, Traynelis, Stephen, Summer, Samantha, Menaldino, David
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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