COMPOUNDS WHICH INHIBIT RNA POLYMERASE

COMPOUNDS WHICH INHIBIT RNA POLYMERASE

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit RNA polymerase I (Pol I). Said chemical entities are useful, e.g., for treating a condition, disease or disorder...

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Hauptverfasser: Liu, Hester Hui, Nv, Rajesh Kumar, de Leon, Pablo, Fan, Wenjun, Laiho, Marikki K, Dorado, Tony, Stachelek, Gregory, Barrow, James C, Begum, Asma
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator Liu, Hester Hui
Nv, Rajesh Kumar
de Leon, Pablo
Fan, Wenjun
Laiho, Marikki K
Dorado, Tony
Stachelek, Gregory
Barrow, James C
Begum, Asma
description This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit RNA polymerase I (Pol I). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) Pol I activity contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title COMPOUNDS WHICH INHIBIT RNA POLYMERASE
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