IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF
The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zink Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of disea...
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creator | Blomgren, Peter A Thomas-Tran, Rhiannon Kim, Musong Venkataramani, Chandrasekar Du, Zhimin Tudesco, Michael T |
description | The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zink Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer. |
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subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
title | IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF |
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