IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF

The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zink Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of disea...

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Hauptverfasser: Blomgren, Peter A, Thomas-Tran, Rhiannon, Kim, Musong, Venkataramani, Chandrasekar, Du, Zhimin, Tudesco, Michael T
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creator Blomgren, Peter A
Thomas-Tran, Rhiannon
Kim, Musong
Venkataramani, Chandrasekar
Du, Zhimin
Tudesco, Michael T
description The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zink Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF
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